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O-GlcNAcase-IN-2

O-GlcNAcase-IN-2 (compound 81) is an orally effective, blood-brain barrier-permeable OGA inhibitor (IC50=4.93 nM). O-GlcNAcase-IN-2 can increase the O-GlcNAcylation level of proteins and phosphorylation of tau (p-Ser199, p-Thr205 and p-Ser396) in the OA-damaged SH-SY5Y cell model. O-GlcNAcase-IN-2 can also improve cognitive impairment in APP/PS1 mice and has potential anti-Alzheimer's disease (AD) effects.

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  • 分子式: C22H26N4OS
  • 分子量:394.53
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • O-GlcNAcase-IN-2 Chemical Structure
    O-GlcNAcase-IN-2 構造式
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  • O-GlcNAcase-IN-2 Chemical Structure
    O-GlcNAcase-IN-2 Chemical Structure
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  • O-GlcNAcase-IN-2