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製品番号: HY-N21624

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Pleioside A

Pleioside A is a flavonoid glycoside with immunomodulatory activity that is found in the leaves of Pleioblastus amarus. Pleioside A exerts differential regulatory effects on adaptive immune lymphocyte proliferation by inhibiting mouse T cell proliferation and promoting B lymphocyte proliferation. Pleioside A can be used for research on adaptive immunity and immunomodulation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 199925-44-5
分子式: C₂₄H₂₆O₁₂
分子量:506.46

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pleioside A 構造式

CAS 番号: 199925-44-5

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Adaptive Immunity

Pleioside A (compound 1) (40 μM; 48 h) inhibits ConA-induced mouse T cell proliferation^[1].
Pleioside A (400 nM-40 μM; 48 h) significantly stimulates LPS (HY-D1056)-induced proliferation of mouse B lymphocytes, with a strong stimulatory effect observed at 40 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

mouse spleen cells
Concentration:

400 nM, 4 μM, 40 μM
Incubation Time:

48 h
Result:

Inhibited ConA-induced T cell proliferation in a concentration-dependent manner.
At 400 nM, ³H-TdR incorporation was 100.68 × 10³ cpm.
At 4 μM, ³H-TdR incorporation decreased to 97.13 × 10³ cpm.
At 40 μM, ³H-TdR incorporation decreased further to 90.18 × 10³ cpm, representing a marked inhibition compared to the ConA positive control value of 107.24 × 10³ cpm.\nStimulated LPS-induced B cell proliferation in a concentration-dependent manner.
At 400 nM, ³H-TdR incorporation was 30.97 × 10³ cpm.
At 4 μM, ³H-TdR incorporation increased to 34.35 × 10³ cpm.
At 40 μM, ³H-TdR incorporation rose further to 40.87 × 10³ cpm, representing a marked stimulation compared to the LPS positive control value of 28.91 × 10³ cpm.

Related Protocols :

化学情報

CAS 番号 199925-44-5
分子量 506.46
分子式 C₂₄H₂₆O₁₂
SMILES

O=C1C2=C(O)C=C(OC)C=C2OC(C3=CC(OC)=C(C(OC)=C3)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1
Structure Classification
- Flavonoids
- Flavones
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Wang HB, et al. Flavone glucosides with immunomodulatory activity from the leaves of Pleioblastus amarus. Phytochemistry. 2004 Apr;65(7):969-74. [Content Brief]

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100 mg

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