PP1 peptide
PP1 peptide is an antagonist that specifically binds to scavenger receptor AI (SR-AI), with an IC50 of 29 μM against bovine SR-AI. By recognizing SR-AI which is highly expressed on macrophages, PP1 peptide enables precise targeting and internalization of inflammatory regions within atherosclerotic plaques. PP1 peptide can be used in research related to atherosclerosis.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 870274-84-3
- 分子式: C79H122N22O22S
- 分子量:1764.01
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
PP1 peptide (0-300 μM) potently inhibits the binding of SR-AI-targeting phages to immobilized recombinant SR-AI, with an IC50 of 29 μM, and its N-terminal region is critical for activity[1].
The PP1 peptide binds to mouse RAW264.7 macrophages in an SR-AI-dependent manner, as demonstrated by fucoidan-mediated inhibition assays, with an IC50 of 4.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
PP1 (0.38 μM; intravenous injection; single administration) selectively targets advanced atherosclerotic plaques in ApoE-/- mice, increases the maximum carrier accumulation by 93.7%, colocalizes with 52.4% of macrophages in plaques, and does not alter plaque size[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ApoE-/- (male, ~65 weeks old, back-crossed for 9 generations on a C57Bl/6 background)[1]
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Dosage:0.38 μM
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Administration:i.v.; single dose
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Result:Showed an 84.12% increase in aortic plaque accumulation compared with untargeted 125I-streptavidin, with no difference in plaque size between groups.
Showed a 93.65% increase in aortic plaque accumulation compared with untargeted Quantumdot Nanocrystals.
Colocalized with 52.4% of intraplaque F4/80-positive macrophages, compared with 6.3% for untargeted Quantumdots.
化学情報
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CAS 番号 870274-84-3
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分子量 1764.01
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分子式 C79H122N22O22S
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SMILES
O=C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N4[C@@H](CCC4)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
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配列
Leu-Ser-Leu-Glu-Arg-Phe-Leu-Arg-Cys-Trp-Ser-Asp-Ala-Pro-Ala
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シーケンスの短縮
LSLERFLRCWSDAPA
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PP1 peptide 関連分類
HY-P12012 関連分類
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