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United States

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製品番号: HY-111026

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PPQ-581

PPQ-581 is an anti-influenza agent with an EC₅₀ of 1 μM for preventing virus-induced cytopathic effects. PPQ-581 inhibits viral protein synthesis. PPQ-581 blocks the RNP nuclear export and cytoplasmic RNP aggregation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 950381-32-5
分子式: C₂₅H₂₄FN₃O₃
分子量:433.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PPQ-581 構造式

CAS 番号: 950381-32-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
MDCK	EC₅₀	1 μM Compound: 6a	Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) assessed as virus-mediated cytopathic effect in MDCK cells after 48 to 72 hrs Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) assessed as virus-mediated cytopathic effect in MDCK cells after 48 to 72 hrs	[PMID: 26310893]
MDCK	EC₅₀	1 μM Compound: 6a	Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein Y52H mutant assessed as virus-mediated cytopathic effect in MDCK cells Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein Y52H mutant assessed as virus-mediated cytopathic effect in MDCK cells	[PMID: 26310893]
MDCK	EC₅₀	1.4 μM Compound: 6a	Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein Y289H mutant assessed as virus-mediated cytopathic effect in MDCK cells Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein Y289H mutant assessed as virus-mediated cytopathic effect in MDCK cells	[PMID: 26310893]
MDCK	EC₅₀	2.3 μM Compound: 6a	Antiviral activity against wild-type Influenza A virus (A/WSN/1933(H1N1)) assessed as virus-mediated cytopathic effect in MDCK cells Antiviral activity against wild-type Influenza A virus (A/WSN/1933(H1N1)) assessed as virus-mediated cytopathic effect in MDCK cells	[PMID: 26310893]
MDCK	EC₅₀	8 μM Compound: 6a	Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein S377G mutant assessed as virus-mediated cytopathic effect in MDCK cells Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein S377G mutant assessed as virus-mediated cytopathic effect in MDCK cells	[PMID: 26310893]

化学情報

CAS 番号 950381-32-5
分子量 433.47
分子式 C₂₅H₂₄FN₃O₃
SMILES

O=C1C2=C(N3C(C(C4=C(F)C=CC=C4)OCC3(C)C)=C2N(C)C(N1C)=O)C5=CC=CC=C5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Lin MI, et al. Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1. Eur J Med Chem. 2015 Sep 18;102:477-86. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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