PROTAC SMARCA2/4 degrader-41
PROTAC SMARCA2/4 degrader-41 is a SMARCA2/4 PROTAC degrader with a DC50 and IC50 both < 0.1 μM. PROTAC SMARCA2/4 degrader-41 is applicable to research on SMARCA2/4-related or SMARCA2/4-deficient cancers.
(Pink: SMARCA2 and SMARCA4 ligand (HY-183063); Blue: VHL ligand (HY-159465); Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2892523-74-7
- 分子式: C49H62N10O6S
- 分子量:919.14
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
SMARCA2 |
SMARCA4 |
VHL |
体外実験
SMARCA2 shares high homology (up to 75%) with SMARCA4. SMARCA4 frequently undergoes mutations (i.e., deletion or inactivation) in primary tumors, particularly in lung cancer (12%), melanoma, liver cancer and pancreatic cancer. In SMARCA4-mutated (deleted) cancer cell lines, SMARCA2 is one of the most critical essential genes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2892523-74-7
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分子量 919.14
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分子式 C49H62N10O6S
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SMILES
OC(C=CC=C1)=C1C2=NN=C(NC3)C(NC3(CC4)CCN4CC5CCN(CC5)CCOC6=NOC([C@@H](C(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(N=CS9)C)C=C8)C)=O)=O)=C6)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PROTAC SMARCA2/4 degrader-41 関連分類
HY-153425 関連分類
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