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製品番号: HY-116053

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PU-11

PU-11 is a Hsp90α/Hsp90β inhibitor with IC₅₀ values of 18.6 μM and 89.8 μM and K_d values of 2 and 4.2 μM. PU-11 binds to the ATP-binding pocket of Hsp90α and Hsp90β and displays selective binding preference for Hsp90α over Hsp90β, mediated by the nonconserved Hsp90α Ser52 residue. PU-11 can be used for the research of neurodegenerative disorders.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1454619-18-1
分子式: C₁₉H₂₃N₅O₃
分子量:369.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

PU-11 構造式

CAS 番号: 1454619-18-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]^[2]

HSP90α

18.6 μM (IC₅₀)

HSP90β

89.8 μM (IC₅₀)

HSP90α

2 μM (Kd)

HSP90β

4.2 μM (Kd)

HSP アイソフォーム固有の製品をすべて表示 :

体外実験

PU-11 (Compound PU-11-trans) (30.1-50.7 μM) binds to purified human Hsp90α NTD with a K_d of 2.0 ± 0.14 μM and an IC₅₀ of 18.6 μM, exhibiting selective affinity for this paralog^[1].
PU-11 (93.3-97.8 μM) binds to purified human Hsp90β NTD with a K_d of 4.2 ± 0.74 μM and an IC₅₀ of 89.8 μM, showing lower affinity than for Hsp90α^[1].
PU-11 (33.0-41.8 μM) binds to purified human Hsp90α^S52A mutant NTD with a K_d of 4.2 ± 0.03 μM, matching its affinity for wild-type Hsp90β^[1].
PU-11 shows IC₅₀ values of 111.4 ± 9.7 and 172.9 ± 7.3 μM for Grp94 and Trap-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

CAS 番号 1454619-18-1
分子量 369.43
分子式 C₁₉H₂₃N₅O₃
SMILES

C(/C=C/C)N1C=2C(N=C1CC3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=CN2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Huck JD, et al. Structures of Hsp90α and Hsp90β bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity. Proteins. 2019;87(10):869-877. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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