PUMA2A
PUMA2A is a PUMA BH3-only peptide. PUMA2A can be used as a negative control in Cytochrome C release assays and BH3 profiling. PUMA2A can be used in the research of chronic myeloid leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C96H156N34O30S
- 分子量:2298.54
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
PUMA-2A (1-100 μM; 2 h) does not induce significant mitochondrial membrane potential loss in K562 CML cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 2298.54
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分子式 C96H156N34O30S
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配列
Ac-Glu-Gln-Trp-Ala-Arg-Glu-Ile-Gly-Ala-Gln-Ala-Arg-Arg-Met-Ala-Ala-Asp-Leu-Asn-Ala-NH2
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シーケンスの短縮
Ac-EQWAREIGAQARRMAADLNA-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[2]. Lucas CM, et al. High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia. Leukemia. 2016;30(6):1273-1281. [Content Brief]
[3]. Butterworth M, et al. BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells. Br J Cancer. 2016;114(6):638-641. [Content Brief]
[4]. Alhuthali HM, et al. The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun. BMC Cancer. 2020;20(1):629. Published 2020 Jul 7. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PUMA2A 関連分類
HY-P11705 関連分類
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