QO-83
Based on 1 Customer Validation
QO-83, Retigabine analogue, is a voltage-gated potassium channel KCNQ2 (Kv7.2) activator with an EC50 of 0.56 μM. QO-83 binds to a single hydrophobic pocket of KCNQ2-CaM complex in closed conformation. QO-83 induces a negative shift in the voltage-dependent activation curve of KCNQ2 channels, increasing the channel's voltage sensitivity. QO-83 can be used for the research of epilepsies.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.58%
- CAS 番号: 2253948-15-9
- 分子式: C22H25F4N3O
- 分子量:423.45
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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KV7.2 0.56 μM (EC50) |
QO-83 (20 μM; 1 h) binds to a single hydrophobic pocket in the PD (S5-S6 interface) of human KCNQ2-CaM complex in closed conformation, inducing conformational rearrangements of the PD and VSD (S3-S4 interface)[1].
QO-83 (10 μM) shifts the voltage-dependent activation curve negatively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2253948-15-9
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性状 Solid
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分子量 423.45
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分子式 C22H25F4N3O
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Color White to off-white
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SMILES
NC1=C(C=CC(NCC2=CC=C(C=C2)C(F)(F)F)=C1F)NC(CCC3CCCC3)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
純度とドキュメンテーション
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データシート (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
QO-83 関連分類
HY-181128 関連分類
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