Sameridine
Sameridine (NIH-10908 free base) is a weak partial agonist of the μ-opioid receptor. Sameridine shows local anesthetic and analgesic properties. Sameridine has minimal respiratory depression at low doses, but can suppress ventilatory response at high doses. Sameridine can be used for the study of analgesic effect.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 143257-97-0
- 分子式: C21H34N2O
- 分子量:330.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Opioid Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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μ Opioid Receptor/MOR |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (weighing 320-420 g)[1].
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Dosage:5 mg/mL (10 μL), 10 mg/mL (10 μL)
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Administration:Intrathecal injection, twice daily, five days a week, for two weeks.
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Result:No permanent motor impairment was observed in any group.
The dorsal horn neurons in the L1 segment of the spinal cord showed normal morphology, and no signs of neurotoxicity were found, such as edema, organelle damage, necrosis, or microglia.
化学情報
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CAS 番号 143257-97-0
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分子量 330.51
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分子式 C21H34N2O
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SMILES
O=C(C1(CCN(CC1)CCCCCC)C2=CC=CC=C2)N(CC)C
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別名
NIH 10908 free base
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Mulroy MF, et al. Sameridine is safe and effective for spinal anesthesia: a comparative dose-ranging study with lidocaine for inguinal hernia repair. Anesth Analg. 1999 Apr;88(4):815-21. [Content Brief]
[2]. Osterlund A, et al. The effects on resting ventilation of intravenous infusions of morphine or sameridine, a novel molecule with both local anesthetic and opioid properties. Anesth Analg. 1999 Jan;88(1):160-5. [Content Brief]
[3]. Karlsten R, et al. Sameridine--intrathecal injection in the rat. Morphometric and morphologic analysis after chronic administration and effects on spinal cord blood flow. Acta Anaesthesiol Scand. 1999 May;43(5):573-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Sameridine 関連分類
HY-105525 関連分類
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