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製品番号: HY-19287

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SQN400

Name: SQN400
Brand: MedChemExpress
SKU: HY-19287
Availability: PreOrder

(別名: m-THPBC)

SQN400 (m-THPBC) is a near-infrared Photosensitizer and singlet oxygen-mediated photodynamic tissue necrosis inducer. SQN400 is activated by near-infrared light at a wavelength of 740 nm. SQN400 exhibits a dose threshold in photodynamic liver necrosis, beyond which the extent of necrosis correlates with the light product. SQN400 induces full-thickness necrosis in implanted mouse colorectal tumors. SQN400 is used in the study of colorectal adenocarcinoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 122341-39-3
分子式: C₄₄H₃₄N₄O₄
分子量:682.78

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SQN400 構造式

CAS 番号: 122341-39-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

Anti-cancerOthers

Anti-cancer

SQN400 (1.2 mg/kg; i.v.; once; 24 h before irradiation) undergoes rapid in vivo photobleaching in Colo26 tumors in BALB/c mice and, in combination with 739 nm light, produces full-thickness tumor necrosis^[1].

Others

SQN400 (0.5 mg/kg; once; 24 h before irradiation) is optimally activated in normal Wistar rat liver under 738.9 nm near-infrared light^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female adult)^[1]
Dosage:

1.2 mg/kg
Administration:

i.v. (tail vein); once; 24 h before irradiation
Result:

Bleached rapidly, with almost no photosensitizer fluorescence detectable from the tumor surface after 30 s of irradiation.
Showed an initial bleaching rate approximately 20 times greater than that of mTHPC under similar conditions.
Produced full-thickness tumor necrosis in all animals at 1.2 mg/kg with 3 J cm^-2 of 739 nm light 24 h after administration, with tumor thickness ranging from 3.7 to 5.0 mm.

化学情報

CAS 番号 122341-39-3
分子量 682.78
分子式 C₄₄H₃₄N₄O₄
SMILES

OC1=CC=CC(=C1)C=2C3=CC=C(N3)C(C=4C=CC=C(O)C4)=C5N=C(C(C=6C=CC=C(O)C6)=C7C=CC(N7)=C(C=8C=CC=C(O)C8)C9=NC2CC9)CC5
別名

m-THPBC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Rovers JP, et al. In vivo photodynamic characteristics of the near-infrared photosensitizer 5,10,15,20-tetrakis(M-hydroxyphenyl) bacteriochlorin. Photochemistry and photobiology. 2000 Sep;72(3):358-64.

[2]. Palumbo G, et al. Photodynamic therapy and cancer: a brief sightseeing tour. Expert opinion on drug delivery. 2007 Mar;4(2):131-48.

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