TAB-004
Based on 1 Customer Validation
TAB-004 is a murine IgG1 monoclonal antibody that specifically binds to the tumor-associated hypoglycosylated mucin 1 (tMUC1), with high selectivity for human tMUC1. TAB-004 can be conjugated with Indocyanine green (ICG) (HY-D0711) for in vivo targeted imaging. TAB-004 can be used for the research of early detection, tumor progression monitoring and cancer stem cell targeting in breast cancer and pancreatic cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 95.45%
- 分子量:145.97 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
MUC1
体外実験
TAB-004 (30 min) specifically binds to human tMUC1-expressing MMT murine breast cancer cells, with no detectable binding to tMUC1-negative PyMT murine breast cancer cells[1].
TAB-004 (3 ng/ml) potently and specifically binds to the MUC1 peptide with detectable binding at 20 pM in a cell-free ELISA[2].
TAB-004 specifically detects human MUC1 in human and murine pancreatic cancer cell lines (KCM, BxPC3.MUC1, HPAF-II) via Western blot, with no cross-reactivity to murine MUC1 in KCKO cells[2].
TAB-004 specifically detects the expression of tMUC1 in BxPC3, PANC-1 and HPAF-II human pancreatic cancer cells by flow cytometry, and can recognize tMUC1 on the surface of more than 95% of Triple+ and CD133+ pancreatic cancer stem cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
TAB-004 (1:500-1:1000 dilution; 2-4 μg/mL) specifically detects human MUC1 on pancreatic cancer cells and > 95% of two distinct pancreatic cancer stem cell populations (CD133+ and Triple+) in athymic nude mouse tumor models, and accurately identifies shed MUC1 in serum from mice with MUC1 high tumors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Mucin-1/MUC1 Protein, Human (357a.a, HEK293, Fc, HY-P78740) can bind TAB-004. The EC50 for this effect is 24.88 ng/mL.
化学情報
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性状 Liquid
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分子量 145.97 kDa
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Color Colorless to light yellow
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SMILES
[TAB-004]
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Moore LJ, et al. Antibody-Guided In Vivo Imaging for Early Detection of Mammary Gland Tumors. Transl Oncol. 2016 Aug;9(4):295-305. [Content Brief]
[2]. Curry JM, et al. The use of a novel MUC1 antibody to identify cancer stem cells and circulating MUC1 in mice and patients with pancreatic cancer. J Surg Oncol. 2013;107(7):713-722. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TAB-004 関連分類
HY-P991319 関連分類
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