Tesirine intermediate-1
Based on 1 Customer Validation
Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
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- 純度: 99.41%
- CAS 番号: 1430738-05-8
- 分子式: C28H48N2O7Si2
- 分子量:580.86
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保管条件:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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CAS 番号 1430738-05-8
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性状 Solid
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分子量 580.86
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分子式 C28H48N2O7Si2
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Color White to off-white
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SMILES
CC(C)[Si](C(C)C)(C(C)C)OC1=C(C=C(C([N+]([O-])=O)=C1)C(N2[C@@H](CC(C2)=O)CO[Si](C)(C)C(C)(C)C)=O)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (172.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
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- Deutsch - DE (393 KB)
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- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7216 mL | 8.6079 mL | 17.2159 mL | 43.0396 mL |
| 5 mM | 0.3443 mL | 1.7216 mL | 3.4432 mL | 8.6079 mL | |
| 10 mM | 0.1722 mL | 0.8608 mL | 1.7216 mL | 4.3040 mL | |
| 15 mM | 0.1148 mL | 0.5739 mL | 1.1477 mL | 2.8693 mL | |
| 20 mM | 0.0861 mL | 0.4304 mL | 0.8608 mL | 2.1520 mL | |
| 25 mM | 0.0689 mL | 0.3443 mL | 0.6886 mL | 1.7216 mL | |
| 30 mM | 0.0574 mL | 0.2869 mL | 0.5739 mL | 1.4347 mL | |
| 40 mM | 0.0430 mL | 0.2152 mL | 0.4304 mL | 1.0760 mL | |
| 50 mM | 0.0344 mL | 0.1722 mL | 0.3443 mL | 0.8608 mL | |
| 60 mM | 0.0287 mL | 0.1435 mL | 0.2869 mL | 0.7173 mL | |
| 80 mM | 0.0215 mL | 0.1076 mL | 0.2152 mL | 0.5380 mL | |
| 100 mM | 0.0172 mL | 0.0861 mL | 0.1722 mL | 0.4304 mL |
Tesirine intermediate-1 関連分類
HY-47820 関連分類
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