Valerate sodium
Based on 1 Customer Validation
Valerate sodium is the sodium salt of valeric acid, a short-chain fatty acid, and exhibits oral activity. Valerate sodium reduces binge ethanol intake and decreases blood ethanol concentration in mice, while also exerting anxiolytic effects. Valerate sodium increases GABA levels, regulates epigenetics and alters gut microbiome function. Valerate sodium can be used in research related to excessive alcohol consumption.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 6106-41-8
- 分子式: C5H9NaO2
- 分子量:124.11
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保管条件:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 6-8 weeks old)[1]
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Dosage:200 mM
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Administration:p.o.; daily; 10 consecutive days
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Result:Reduced ethanol consumption by 40%.
Lowered blood ethanol concentration by 53%.
Increased percentage of time spent in the center of the open field and number of center entries, with no change in total distance traveled.
Elevated GABA levels in stool and amygdala.
Increased H4 histone acetylation in the amygdala.
Induced significant changes in amygdala gene expression, including upregulation of Kcna10, Pln, and Gpr56, and downregulation of Ptgs2, Mapks, and Gpr158; associated pathways included glutamate degradation, L-DOPA degradation, and anti-inflammatory effects.
Altered gut microbiome composition, with increased abundance of genera Ileibacterium and Dubosiella; reduced gut-brain module activity for GABA degradation and 7 other neuroactive compound pathways.
No significant effects on body weight, food intake, or fluid intake compared to controls.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 6106-41-8
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性状 Solid
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分子量 124.11
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分子式 C5H9NaO2
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Color White to off-white
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SMILES
O=C(O[Na])CCCC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
溶剤 & 溶解度
H2O : 200 mg/mL (1611.47 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.0574 mL | 40.2868 mL | 80.5737 mL | 201.4342 mL |
| 5 mM | 1.6115 mL | 8.0574 mL | 16.1147 mL | 40.2868 mL | |
| 10 mM | 0.8057 mL | 4.0287 mL | 8.0574 mL | 20.1434 mL | |
| 15 mM | 0.5372 mL | 2.6858 mL | 5.3716 mL | 13.4289 mL | |
| 20 mM | 0.4029 mL | 2.0143 mL | 4.0287 mL | 10.0717 mL | |
| 25 mM | 0.3223 mL | 1.6115 mL | 3.2229 mL | 8.0574 mL | |
| 30 mM | 0.2686 mL | 1.3429 mL | 2.6858 mL | 6.7145 mL | |
| 40 mM | 0.2014 mL | 1.0072 mL | 2.0143 mL | 5.0359 mL | |
| 50 mM | 0.1611 mL | 0.8057 mL | 1.6115 mL | 4.0287 mL | |
| 60 mM | 0.1343 mL | 0.6714 mL | 1.3429 mL | 3.3572 mL | |
| 80 mM | 0.1007 mL | 0.5036 mL | 1.0072 mL | 2.5179 mL | |
| 100 mM | 0.0806 mL | 0.4029 mL | 0.8057 mL | 2.0143 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Valerate sodium 関連分類
HY-W007087 関連分類
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