β-Amanitin
Based on 1 Customer Validation
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 92.9%
- CAS 番号: 21150-22-1
- 分子式: C39H53N9O15S
- 分子量:919.95
-
保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-19610
α-AmanitinADC Toxin/RNA Pol II Inhibitor -
HY-10162
OlaparibPARP Inhibitor -
HY-131081
γ-AmanitinADC Cytotoxin -
HY-134539
IMT1POLRMT Inhibitor -
HY-P0028
PhalloidinF-actin Label -
HY-K0301
Cell Counting Kit-8 -
HY-N1548
PrunasinDNA Polymerase β Inhibitor -
HY-N7719
OosporeinMicrobial Metabolite -
HY-103447S1
Zearalenone-13C18Mycotoxin Compound -
HY-P2031
PhallacidinF-actin Stabilizer -
HY-129589
Thailanstatin ARNA Splicing Inhibitor -
HY-113606
Adenosine 5'-phosphosulfate disodiumMetabolism intermediates
生物活性
製品説明
IC50 & Target
[1]|
RNA Polymerase |
Traditional Cytotoxic Agents |
体外実験
β-Amanitin (0.01-100 μg/mL; 36 hours) shows toxicity in MCF-7 cells, and the rates of cell viability are calculated as 52%, 62%, 84%, 86%, and 91% at concentrations of 100, 10, 1, 0.1, and 0.01 μg/mL, respectively[2].
β-Amanitin shows a great inhibition of protein synthesis at both concentrations (10 μg/mL and 1 μg/mL) in MCF-7 cells for 24 hours[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7 cells
-
Concentration:0.01, 0.1, 1, 10, 100 µg/mL
-
Incubation Time:36 hours
-
Result:Showed toxicity in MCF-7 cells.
化学情報
-
CAS 番号 21150-22-1
-
性状 Solid
-
分子量 919.95
-
分子式 C39H53N9O15S
-
Color White to off-white
-
別名
β-アマニチン
-
配列
Ile-{6-hydroxy-Trp}-Gly-Ile-Gly-Cys-Asn-Pro (Sulfidebridge try4-cys8)
-
シーケンスの短縮
D-{6-hydroxy-Trp}-IWGIGC (Sulfidebridge try4-cys8)
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 20 mg/mL (21.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 10 mg/mL (10.87 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (281 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.0870 mL | 5.4351 mL | 10.8702 mL | 27.1754 mL |
| 5 mM | 0.2174 mL | 1.0870 mL | 2.1740 mL | 5.4351 mL | |
| 10 mM | 0.1087 mL | 0.5435 mL | 1.0870 mL | 2.7175 mL | |
| DMSO | 15 mM | 0.0725 mL | 0.3623 mL | 0.7247 mL | 1.8117 mL |
| 20 mM | 0.0544 mL | 0.2718 mL | 0.5435 mL | 1.3588 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
β-Amanitin 関連分類
HY-125586 関連分類
Powered by Bioz