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Cat. No.: HY-159675

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1-A-N

1-A-N is a lipid nanoparticle (LNP) used for in vivo delivery of siRNA. 1-A-N can regulate immune response by delivering siCD45 (siRNA targeting CD45) to T cells and silencing the CD45 gene.

For research use only. We do not sell to patients.

Formula: C₄₂H₆₇NO₇
Molecular Weight:697.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (261 KB)

1-A-N Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

1-A-N is a lipid nanoparticle (LNP) used for in vivo delivery of siRNA. 1-A-N can regulate immune response by delivering siCD45 (siRNA targeting CD45) to T cells and silencing the CD45 gene^[1].

Chemical Information

Molecular Weight 697.98
Formula C₄₂H₆₇NO₇
SMILES

CC/C=C\C/C=C\C/C=C\CCCCCCCC(OCC(COC(CC12C[C@H]3C[C@@H](C2)C[C@H](C3)C1)=O)COC(OCCCN4CCCC4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lokugamage M P, et al. Constrained nanoparticles deliver siRNA and sgRNA to T cells in vivo without targeting ligands[J]. Advanced Materials, 2019, 31(41): 1902251. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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