F2RL1 - F2R like trypsin receptor 1 Gene

Also Known as PAR2; GPR11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2150

About F2RL1

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,819,030-76,835,315 (from NCBI)

This gene has 2 transcripts (splice variants), 307 orthologues and 16 paralogues. Broad expression in colon (RPKM 30.3), duodenum (RPKM 21.7) and 16 other tissues.

Summary

This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]

F2RL1 Products (1)

mRNA	Protein	Name
NM_005242.6	NP_005233.4	proteinase-activated receptor 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	18622013	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	18434511	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10725339	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28445455	GOA
involved in cell-cell junction maintenance	IMP IMP: Inferred from mutant phenotype	23202369	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	18453611	GOA
involved in establishment of endothelial barrier	IDA IDA: Inferred from direct assay	20826780	GOA
involved in leukocyte migration	IDA IDA: Inferred from direct assay	15155775	GOA
involved in mature conventional dendritic cell differentiation	IDA IDA: Inferred from direct assay	16478888	GOA
involved in negative regulation of JNK cascade	IDA IDA: Inferred from direct assay	19781631	GOA
involved in negative regulation of chemokine production	IDA IDA: Inferred from direct assay	19865078	GOA
involved in negative regulation of toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	19865078	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	19781631	GOA
involved in neutrophil activation	IDA IDA: Inferred from direct assay	15155775	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	10725339	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	23202369	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	11413129	GOA
involved in positive regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	20826780	GOA
involved in positive regulation of actin filament depolymerization	IDA IDA: Inferred from direct assay	17500066	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11413129	GOA
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	19494303	GOA
involved in positive regulation of cytokine production involved in immune response	IDA IDA: Inferred from direct assay	11441110	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	10725339	GOA
involved in positive regulation of eosinophil degranulation	IDA IDA: Inferred from direct assay	11714832	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	15155775	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	18453611	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	11447194	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	15155775	GOA
involved in positive regulation of leukocyte chemotaxis	IDA IDA: Inferred from direct assay	17991872	GOA
involved in positive regulation of neutrophil mediated killing of gram-negative bacterium	IDA IDA: Inferred from direct assay	21501162	GOA
involved in positive regulation of phagocytosis, engulfment	IDA IDA: Inferred from direct assay	21501162	GOA
involved in positive regulation of positive chemotaxis	IDA IDA: Inferred from direct assay	17991872	GOA
involved in positive regulation of superoxide anion generation	IDA IDA: Inferred from direct assay	11714832	GOA
involved in positive regulation of toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	19865078	GOA
involved in positive regulation of toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	19865078	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	18622013	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16410250	GOA
involved in regulation of JNK cascade	IDA IDA: Inferred from direct assay	16410250	GOA
involved in regulation of blood coagulation	IDA IDA: Inferred from direct assay	17848177	GOA
involved in regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	18453611	GOA
involved in regulation of chemokine (C-X-C motif) ligand 2 production	IDA IDA: Inferred from direct assay	21501162	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	22547407	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17848177	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2RL1 Protein Structure

7tm_1

0
100
200
300
397 a.a.

Protein Preferred Names	Protein Names
proteinase-activated receptor 2	G-protein coupled receptor 11 coagulation factor II (thrombin) receptor-like 1 protease-activated receptor 2 thrombin receptor-like 1

F2RL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	F2RL1	P55085	EPR-1	Homo sapiens	Q14868	Anti Bait CoIP	20826780
Intra	F2RL1	P55085	CBL	Homo sapiens	P22681	Anti Bait CoIP	15708858
Intra	F2RL1	P55085	CBL	Homo sapiens	P22681	Confocal	15708858
Intra	F2RL1	P55085	COPS5	Homo sapiens	Q92905	Y2H	16410250
Intra	F2RL1	P55085	COPS5	Homo sapiens	Q92905	Confocal	16410250
Intra	F2RL1	P55085	COPS5	Homo sapiens	Q92905	Anti Tag CoIP	16410250
Intra	F2RL1	P55085	COPS5	Homo sapiens	Q92905	Pull Down	16410250
Intra	F2RL1	P55085	TMED2	Homo sapiens	Q15363	Anti Tag CoIP	17693410
Intra	F2RL1	P55085	TMED2	Homo sapiens	Q15363	Y2H	17693410
Intra	F2RL1	P55085	TMED2	Homo sapiens	Q15363	Pull Down	17693410

Cross: Cross-species interaction Intra: Intraspecies interaction

F2RL1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82710	PAR2 Antibody (YA2455)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P82710A	PAR2 Antibody (YA2455)(PBS only)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pancreatitis	Mumps Pancreatitis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Alzheimer Disease 12	Ad12 Alzheimer'S Disease 12 Alzheimer Disease, Familial, 12 Alzheimer Disease Familial 12
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Granulomatous Orchitis	Non-Specific Granulomatous Orchitis
Vernal Keratoconjunctivitis	Vkc Spring Catarrh Keratoconjunctivitis Vernal Keratoconjunctivitis, Vernal
Neuroleptic Malignant Syndrome
Rhinitis	Runny Nose
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04634	F2RL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04635	F2rl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04636	F2rl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	F2RL1	VGNC	VGNC:28684
Canis familiaris	F2RL1	VGNC	VGNC:40549
Mus musculus	F2RL1	MGD	MGI:101910
Macaca mulatta	F2RL1	VGNC	VGNC:110468
Rattus norvegicus	F2RL1	RGD	RGD:620866
Others	F2RL1	NCBI