Serpine2 - serpin family E member 2 Gene

Also Known as CRG; PI-7; Pn-1; Spin4; Gdnpn1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29366

Summary

Enables heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including dense core granule biogenesis; embryo implantation; and negative regulation of blood coagulation. Located in extracellular space; membrane; and neuronal cell body. Biomarker of brain edema and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (Serpin family E member 2). [provided by Alliance of Genome Resources, Apr 2022]

Serpine2 Products (1)

mRNA Protein Name
NM_019197.1 NP_062070.1 glia-derived nexin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparin binding IDA
IDA: Inferred from direct assay
19167525 RGD
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
19167525 RGD
Biological Process GO Annotation Evidence References Source
involved in dense core granule biogenesis IDA
IDA: Inferred from direct assay
16319172 RGD
involved in embryo implantation IEP
IEP: Inferred from expression pattern
11457471 RGD
involved in negative regulation of blood coagulation IDA
IDA: Inferred from direct assay
17379830 RGD
involved in negative regulation of proteolysis IDA
IDA: Inferred from direct assay
17379830 RGD
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
19167525 RGD
involved in secretory granule organization IDA
IDA: Inferred from direct assay
16319172 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
16192390 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
9751132 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glia-derived nexin

  • Clozapine Regulated Gene

  • GDN

  • Glia-derived nexin/protease nexin I

  • glia-derived nexin / preotease nexin I

  • peptidase inhibitor 7

  • plasminogen activator inhibitor type 1

  • protease nexin 1

  • protease nexin I

  • protease nexin PN-1

  • serine (or cysteine) peptid

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12723 SERPINE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17933 Serpine2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24403 Serpine2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Serpine2 NCBI NCBI:5270