3FAx-Neu5Ac
Based on 5 publication(s) in Google Scholar
3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.88%
- CAS No.: 117405-58-0
- 화학식: C22H30FNO14
- 분자량:551.47
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 3FAx-Neu5Ac
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Customer Validation & Images
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Flow Cytometry
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Bio/Physico-chemical Assay
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Cell Imaging/Staining
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WB
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Biological Activity
제품 설명
In Vitro
3FAx-Neu5Ac (300 μM, 7 days) reduces sialylation on HECA-452 MM1S cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 117405-58-0
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Appearance Solid
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분자량 551.47
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화학식 C22H30FNO14
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Color White to off-white
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SMILES
COC([C@]1(O[C@@]([C@H](NC(C)=O)[C@@H](OC(C)=O)[C@H]1F)([H])[C@H](OC(C)=O)[C@H](OC(C)=O)COC(C)=O)OC(C)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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Research (Wash D C)
Small-Molecule Boron-10-Enriched Carriers with Exceptional Aqueous Solubility for Enhanced Boron Neutron Capture Therapy of Malignant Tumors. [Abstract]2026 Jul 3:9:1315. PMID: 42404354 -
NPJ Breast Cancer
CD52 signaling via macrophage Siglec-G represents a therapeutic target for cancer immunotherapy. [Abstract]2026 Jan 24;12(1):29. PMID: 41580422
3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: NPJ Breast Cancer. 2026 Jan 24;12(1):29. [Abstract]
Macrophage phagocytosis of 4T1 cells pretreated with PBS control or sialic acid inhibitor 3FAx-Neu5Ac (100 μM; 24 h). 3FAx-Neu5Ac mediated sialic acid removal in 4T1 cells remarkably enhanced macrophage phagocytosis of tumor cells.
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Food Funct
Theabrownin derived from Pu-erh tea enhances intestinal barrier integrity and microbiota balance via the ST6GalNAc6-STn-MUC2 axis in inflammation. [Abstract]2026 Apr 27. PMID: 42037092 -
3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Aug 08.
3FAX-Neu5Ac (0-200 μM; 24 h) inhibited sialic acid modification in HCT116 cells in a dose-dependent manner.
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3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 June 02.
Fluorescent microscopy of lectin binding in 3FAx-Neu5Ac-treated WT MDBK cells. 3Fax-Neu5Ac (200 μM; 10 d) effectively depleted α2,3/α2,6-linked sialic acids in MDBK cells.
3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 June 02.
MDBK cells were treated with either DMSO or 3FAx-Neu5Ac (200 μM; 10 d) and subsequently infected with BPIV3 at a MOI of 1. After 24 hours, The levels of viral nucleoprotein (NP) replication within the cells were assessed as a measure of infection.
3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 June 02.
Primary bovine nasal turbinate cells were isolated and treated with 3Fax-Neu5Ac (200 μM; 10 d) to investigate the distribution of sialic acids. A significant reduction in cell surface sialic acid levels was observed following treatment with the 3Fax-Neu5Ac inhibitor.
용액&용해도
In Vitro:
DMSO : 100 mg/mL (181.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
순도&문서
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8133 mL | 9.0667 mL | 18.1334 mL | 45.3334 mL |
| 5 mM | 0.3627 mL | 1.8133 mL | 3.6267 mL | 9.0667 mL | |
| 10 mM | 0.1813 mL | 0.9067 mL | 1.8133 mL | 4.5333 mL | |
| 15 mM | 0.1209 mL | 0.6044 mL | 1.2089 mL | 3.0222 mL | |
| 20 mM | 0.0907 mL | 0.4533 mL | 0.9067 mL | 2.2667 mL | |
| 25 mM | 0.0725 mL | 0.3627 mL | 0.7253 mL | 1.8133 mL | |
| 30 mM | 0.0604 mL | 0.3022 mL | 0.6044 mL | 1.5111 mL | |
| 40 mM | 0.0453 mL | 0.2267 mL | 0.4533 mL | 1.1333 mL | |
| 50 mM | 0.0363 mL | 0.1813 mL | 0.3627 mL | 0.9067 mL | |
| 60 mM | 0.0302 mL | 0.1511 mL | 0.3022 mL | 0.7556 mL | |
| 80 mM | 0.0227 mL | 0.1133 mL | 0.2267 mL | 0.5667 mL | |
| 100 mM | 0.0181 mL | 0.0907 mL | 0.1813 mL | 0.4533 mL |
3FAx-Neu5Ac Related Classifications
HY-110288 Related Classifications
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