Antimicrobial agent-57

Antimicrobial agent-57 (compound A6) (50 mg/L) exhibits the most potent antioomycete activity against P. capsici with an EC₅₀ of 1.24 mg/L^[1].
Antimicrobial agent-57 (1.24 mg/L) causes significant morphological damage to P. capsici hyphae, resulting in desiccation, shriveling, and partial degradation^[1].
Antimicrobial agent-57 (1.24 mg/L) causes significant toxicological damage to the cellular ultrastructure of P. capsici, including cell wall thickening, lipid droplet reduction, mitochondrial degradation, and vacuole enlargement^[1].
Antimicrobial agent-57 (5-20 mg/L; 1-5 h) significantly inhibits the respiration of P. capsici in a time- and concentration-dependent manner^[1].
Antimicrobial agent-57 (5 mg/L) inhibits mitochondrial complex III activity of P. capsici with an IC₅₀ of 8.82 mg/L, suggesting that its antioomycete activity is mediated by targeting complex III^[1].
Antimicrobial agent-57 binds to the Qo site of P. capsici complex III primarily through hydrophobic interactions (alkyl, π-alkyl, and π-sigma) with a binding energy of −7.6 kcal/mol^[1].
The excellent antioomycete activity of Antimicrobial agent-57 arises from favorable HOMO/LUMO localization and a concentrated MEP distribution on the key pharmacophore, enabling efficient targeting of mitochondrial complex III^[1].
Antimicrobial agent-57 (100-400 mg/L) exhibits no significant adverse effects on seed germination or plant growth of chili pepper, indicating favorable biosafety^[1].