Arcapillin
Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin induces dose-dependent relaxation of ileum and pulmonary artery smooth muscle, causes slight urinary bladder smooth muscle contraction at highest tested concentrations. Arcapillin binds to the active site of SARS-CoV-2 Mpro via interactions with Gln139, His163, and His164, exhibits antiviral activity against SARS-CoV-2 and MERS-CoV. Arcapillin can be used for the research of gastrointestinal disorders, COVID-19, and Middle East respiratory syndrome (MERS).
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- CAS No.: 83162-82-7
- 화학식: C18H16O8
- 분자량:360.31
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
PTP1B[1]
Arcapillin binds to the SARS-CoV-2 main protease (PDB: 7L0D) with a docking score of -6.16 kcal mol−1, indicating favorable interactions with the enzyme's active site[2].
Arcapillin (72 h) exhibits antiviral activity against SARS-CoV-2 in Vero E6 cells with an IC50 of 190.8 μg mL−1, and has a low cytotoxic profile in the same cell line with a CC50 of 1228 μg mL−1, yielding a selectivity index of 6.40[2].
Arcapillin (72 h) exhibits potent antiviral activity against MERS-CoV in Vero E6 cells with an IC50 of 16.58 μg mL−1, and has a CC50 of 54.17 μg mL−1 in the same cell line, yielding a selectivity index of 3.26[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 83162-82-7
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분자량 360.31
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화학식 C18H16O8
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SMILES
O=C1C=C(C2=CC(OC)=C(O)C=C2O)OC3=CC(OC)=C(OC)C(O)=C13
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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