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Cat. No.: HY-174820

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AZ'320

AZ'320 is an ATP-competitive necroptosis (EC₅₀ of 4.9 μM) inhibitor and a RIPK1 (pK_D of 5.45) inhibitor. AZ'320 inhibits necroptosis by inhibiting RIPK1 phosphorylation. AZ’320 prevents mortality of the mice and rescues temperature and body weight in SIRS mice models. AZ'320 can be used for researches of cancer and inflammation.

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화학식: C₂₀H₂₀N₂O₄S₂
분자량:416.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AZ'320 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All RIP kinase Isoforms :

In Vitro

AZ’320 (0.1-10 μM, 4 h) dose-dependently inhibits the levels of RIPK1 Ser166 phosphorylation in I2.1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

I2.1 FADD^−/− human Jurkat cells
Concentration:

01, 1, 5 and 10 μM
Incubation Time:

4 h
Result:

Dose-dependently inhibited the levels of RIPK1 Ser166 phosphorylation.

In Vivo

AZ’320 (5 mg/kg, i.v., 15 min before TNF stimulation) prevents mortality of the mice and rescues temperature and body weight to a similar degree as Nec-1 (HY-15760) in SIRS mice models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Systemic inflammatory response syndrome (SIRS) mice models (C57BL/6, male, 6-8 weeks)^[1]
Dosage:

5 mg/kg
Administration:

Intravenously injection, 15 min before 96 h of 0.5 mg/kg TNF stimulation
Result:

Prevented mortality of the mice and rescued temperature and body weight to a similar degree as Nec-1 (HY-15760).

Chemical Information

분자량 416.51
화학식 C₂₀H₂₀N₂O₄S₂
SMILES

O=S(C1=CC=C(C2=CC=C3C=CC=NC3=C2)C=C1)(N4CC(CS(=O)(C)=O)C4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Soday L, et al. Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1. ACS Chem Biol. 2025 Jun 20. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

AZ'320

All RIP kinase Isoforms