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Cat. No.: HY-N19296

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Blapsin B

Blapsin B is a potent 14-3-3 inhibitor and a naturally occurring compound from Blaps japanensis. Blapsin B potently inhibits 14-3-3 protein-protein interactions (PPIs) with an IC₅₀ value of 10.0 μM in the ELISA assay and 2.5 μM in the FP assay, respectively. Blapsin B modulates signaling pathways involved in cell proliferation and transformation. Blapsin B can be used for cancer research.

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CAS No.: 861145-00-8
화학식: C₁₅H₁₄O₅
분자량:274.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Blapsin B Chemical Structure

CAS No.: 861145-00-8

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Blapsin B (10 μM) potently inhibits 14-3-3γ protein-protein interactions in an ELISA assay with an IC₅₀ of 10.0 μM^[1].
Blapsin B (2.5 μM) potently inhibits 14-3-3 protein-protein interactions in an FP assay with an IC₅₀ of 2.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 861145-00-8
분자량 274.27
화학식 C₁₅H₁₄O₅
SMILES

OC1=CC=C(C2OCCC3=CC(O)=C(C=C32)O)C=C1O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Animals
from the insect Blaps japanensis
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yan YM, et al. Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis. Bioorg Med Chem Lett. 2012;22(12):4179-4181. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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