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Cat. No.: HY-120130

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BMS-948

BMS-948 is a RARβ-selective transcriptional agonist with an EC₅₀ of 0.1 μM. BMS-948 is used in the research of tumor diseases, embryonic development and tissue remodeling.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 168901-49-3
화학식: C₂₄H₁₇NO₃
분자량:367.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMS-948 Chemical Structure

CAS No.: 168901-49-3

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

BMS-948 is a RARβ-selective transcriptional agonist with an EC₅₀ of 0.1 μM. BMS-948 is used in the research of tumor diseases, embryonic development and tissue remodeling^[1].

IC₅₀ & Target

RXRβ

0.1 μM (EC₅₀)

All RAR/RXR Isoforms :

In Vitro

BMS-948 acts as a fully selective agonist of RARβ in HeLa cells, with an EC₅₀ of 0.1 μM for RARβ-mediated transactivation, and exhibits extremely low activity against RARα and RARγ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 168901-49-3
분자량 367.40
화학식 C₂₄H₁₇NO₃
SMILES

O=C(O)C1=CC=C(C=C1)NC(=O)C2=CC=C3C=CC=C(C=4C=CC=CC4)C3=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Nadendla E, et al. An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist. PLoS One. 2015;10(5):e0123195. Published 2015 May 1. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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BMS-948

All RAR/RXR Isoforms