BO-653
BO-653 is an orally active anti-atherosclerotic antioxidant that exhibits high binding affinity for LDL. BO-653 scavenges linoleic acid peroxyl radicals, inhibits lipid peroxidation during the auto-oxidation of linoleic acid, and potently suppresses LDL oxidation. BO-653 inhibits Hepatitis C Virus (HCV) replication in a concentration-dependent manner, with an IC50 of 36.0 μM against the HCV subgenomic replicon in FLR3-1 cells. BO-653 demonstrates significant anti-atherosclerotic effects in various animal models, including the Watanabe heritable hyperlipidemic rabbit. BO-653 is suitable for use in research related to atherosclerosis and Hepatitis C Virus infection.
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- CAS No.: 157360-23-1
- 화학식: C26H44O2
- 분자량:388.63
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
BO-653 (1f) (10 min) potently inhibits linoleic acid autoxidation in a cell-free assay with an IC50 of 4.6 μM[1].
BO-653 (24 h) inhibits both SLO‑ and CuSO4‑induced oxidation of rabbit LDL[1].
BO-653 (1, 10 μM; 24 h) potently reduces electrophoretic mobility changes in CuSO4-oxidized rabbit LDL, with 1 μM treatment resulting in mobility similar to native LDL[1].
BO-653 (1, 10 μM; 24 h) potently reduces electrophoretic mobility changes in SLO-oxidized rabbit LDL[1].
BO-653 (12-1000 μM; 72 hours) inhibits HCV replication in a concentration-dependent manner in FLR3-1 and RMT-tri cells (IC50 = 36.0 μM in FLR3-1 cells) without exhibiting cytotoxicity[2].
BO-653 (0-1000 μM; 96 hours) reduces HCV NS3 protein levels in a concentration-dependent manner in FLR3-1 cells[2].
BO-653 (72 hours) demonstrates stronger anti-HCV activity in FLR3-1 cells than both lipophilic and hydrophilic antioxidants[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FLR3-1 and RMT-tri cells
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Concentration:12, 37, 111, 333, 1000 μM
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Incubation Time:72 h
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Result:Inhibited HCV replication in a concentration-dependent manner in FLR3-1 and RMT-tri cells (IC50 = 36.0 μM in FLR3-1 cells) without exhibiting cytotoxicity.
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Cell Line:FLR3-1 cells
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Concentration:12, 37, 111, 333, 1000 μM
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Incubation Time:96 h
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Result:significantly reduced HCV NS3 protein expression in FLR3-1 cells in a concentration-dependent manner.
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Cell Line:FLR3-1 cells
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Concentration:111 μM
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Incubation Time:72 h
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Result:Reduced HCV core protein expression.
| Species | Dose | Route | Plasma Concentration |
|---|---|---|---|
| Rabbit[1] | 250 mg/kg | p.o. | 2.22 μg/mL |
BO-653 (2000 mg/kg; p.o.; once daily; 14 days) shows no reduction of serum HCV RNA titer in HCV-infected chimeric uPA/SCID mice, and significantly enhances the anti-HCV effect of PEG-IFN by decreasing serum and liver HCV RNA levels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 157360-23-1
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분자량 388.63
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화학식 C26H44O2
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SMILES
OC1=C(C(C)(C)C)C2=C(OC(CCCCC)(CCCCC)C2)C=C1C(C)(C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Tamura K, et al. Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants. J Med Chem. 2003;46(14):3083-3093. [Content Brief]
[2]. Yasui F, et al. Synthetic lipophilic antioxidant BO-653 suppresses HCV replication. J Med Virol. 2013 Feb;85(2):241-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BO-653 Related Classifications
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