BSP16
Based on 1 Customer Validation
BSP16 is a potent, orally active stimulator of interferon genes (STING) agonist. BSP16 can selectively stimulate the STING pathway. BSP16 can be used for the research of cancer.
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- Purity: 98.3%
- CAS No.: 2727249-47-8
- 화학식: C16H18O5Se
- 분자량:369.27
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50 for STING: 9.24 μM (ISG-THP1 cells); 5.71 μM (ISGRAW264.7 cells)[1]
BSP16 (0.1-100 μM) can selectively stimulate the STING pathway in ISG-THP1 and ISGRAW264.7 cells with EC50 values of 9.24 and 5.71 μM, respectively[1].
BSP16 (10, 25, 50 μM; 1, 3, 6 h) strongly activates STING signaling in human and mouse cells and binds STING as a homodimer[1].
BSP16 exhibits a promising absorption, distribution, metabolism, excretion and toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ISG-THP1 cells
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Concentration:10, 25, 50 μM
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Incubation Time:1, 3, 6 h
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Result:Robustly induced mRNA expression of target genes IFNβ, CXCL10, and IL6 in response to STING activation, in a time and concentration-dependent manner in ISGTHP1 cells.
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Cell Line:ISG-THP1 cells
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Concentration:10, 25, 50 μM
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Incubation Time:1, 3, 6 h
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Result:Rapidly increased the phosphorylation of TBK1 and IRF3 in a concentration-dependent manner.
BSP16 (oral, 15 and 30 mg/kg, q3d; oral, 20 mg/kg, q5d) induces tumor regression and durable antitumor immunity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MC38 (colon carcinoma) syngeneic tumor model[1]
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Dosage:15, 30 mg/kg
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Administration:oral, q3d
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Result:Exhibited tolerated and excellent antitumor efficacy, experienced complete tumor regression (CR) after day 21.
Resulted in robust induction of IFNB and IL6 (30 mg/kg).
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Animal Model:CT26 (colon carcinoma) tumor model[1]
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Dosage:20 mg/kg
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Administration:oral, q5d
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Result:Exhibited tolerated and induced tumor regression in all treated mice within 30 days.
Led to a substantial elevation of IFNB in the plasma in CT26 bearing mice.
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Animal Model:Rats[1]
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Dosage:5 mg/kg, 50 mg/kg
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Administration:oral and i.v
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Result:
compd. adm. Cmax(μg/mL) AUG0-∞(h*μg/mL) t1/2(h) Vss(L/kg) CL(L/h/kg) F(%) BSP16 po(50 mg/kg) 58.2 315.9 1.60 0.38 0.16 107 iv(5 mg/kg) 29.4 1.04 0.26 0.17
Chemical Information
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CAS No. 2727249-47-8
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Appearance Solid
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분자량 369.27
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화학식 C16H18O5Se
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Color Light yellow to yellow
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SMILES
OC([C@H](CC)CC(C1=CC2=CC(OC)=C(OC)C=C2[Se]1)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BSP16 Related Classifications
HY-151264 Related Classifications
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