CGP-49823
CGP-49823 is an orally active and highly selective antagonist of the neurokinin 1 receptor (NK1 receptor). CGP-49823‘s potency is significantly higher in isolated spinal cords of hamsters than in those of rats. CGP 49823 exhibits a significant anti-anxiety effect in social interaction experiments of rats, and its tolerance develops slowly, without causing anxiety-like withdrawal reactions after discontinuation. CGP-49823 can be used in anxiety and depression research.
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- CAS No.: 150705-88-7
- 화학식: C31H33N3O
- 분자량:463.61
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-373MG ATCC | IC50 |
12 nM
Compound: (+)-2, (CGP-49823)
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Compound was tested for inhibition of substance P induced phosphatidyl inositol turnover in human U-373 cells
Compound was tested for inhibition of substance P induced phosphatidyl inositol turnover in human U-373 cells
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10.1016/0960-894X(96)00287-9 |
Chemical Information
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CAS No. 150705-88-7
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분자량 463.61
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화학식 C31H33N3O
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SMILES
O=C(N1[C@H](CC2=CC=CC=C2)C[C@@H](NCC3=CC=NC4=CC=CC=C34)CC1)C5=CC(C)=CC(C)=C5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. File SE. Anxiolytic action of a neurokinin1 receptor antagonist in the social interaction test. Pharmacol Biochem Behav. 1997 Nov;58(3):747-52. [Content Brief]
[2]. Pozza MF, et al. The potency of the novel tachykinin receptor antagonist CGP49823 at rat and gerbil motoneurones in vitro. Eur J Pharmacol. 1998 Jan 26;342(2-3):203-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CGP-49823 Related Classifications
HY-19203 Related Classifications
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