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Cat. No.: HY-158726

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Complex 3

Complex 3 is a fluorescent dithiocarbazate-copper complex with anticancer activity, which localizes to mitochondria. Complex 3 displays excitation/emission maxima of 455-495/535 nm, respectively. Complex 3 inhibits the growth of BxPC-3, AsPC-1, PANC-1, and WI38 pancreatic cancer cells with IC₅₀ values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. Complex 3 induces lipid peroxidation and mitochondrial rupture and shrinkage in AsPC-1 cells. Complex 3 also induces mitochondrial apoptosis and cytokine-cytokine receptor interaction dysfunction in AsPC-1 cells. Complex 3 reduces tumor volume in an AsPC-1 mouse xenograft model.

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CAS No.: 2480150-28-3
화학식: C₂₆H₂₂Br₃Cu₃N₈S₄
분자량:1005.12

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Complex 3 Chemical Structure

CAS No.: 2480150-28-3

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

Chemical Information

CAS No. 2480150-28-3
분자량 1005.12
화학식 C₂₆H₂₂Br₃Cu₃N₈S₄
SMILES

[Br-][Cu+2]1([S-]2)[N](N=C2SC)=C(C3=CC=CC=[N]3[Cu+]([N]4=CC=CC=C4C(C5=CC=CC=[N]56)=[N](N=C7SC)[Cu+2]6([S-]7)[Br-])[Br-])C8=CC=CC=[N]81
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gou Y, et al. Dithiocarbazate-Copper Complexes for Bioimaging and Treatment of Pancreatic Cancer. J Med Chem. 2021 May 13;64(9):5485-5499. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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