DCPD
Based on 1 Customer Validation
DCPD is an amine substance with both embryotoxicity and teratogenicity, and its total effect ED50 is 0.6 μmol per egg. DCPD induces early and late embryonic death, and causes multiple embryonic malformations including microcephaly, hypoplastic optic cup, eyelid and corneal defects. DCPD can serve as a calcium phosphate additive for biomimetic α-tricalcium phosphate bone cement, which inhibits the transformation of α-tricalcium phosphate into calcium-deficient hydroxyapatite, blocks the release of Gelatins (HY-Y1365), and effectively prolongs the setting time of bone cement. DCPD is applicable to studies related to embryonic malformations.\n
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- Purity: 95.0%
- CAS No.: 4175-38-6
- 화학식: C18H28N2
- 분자량:272.43
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
DCPD prolongs the initial and final setting times of gelatin-α-TCP bone cement, and 15 wt.% DCPD completely inhibits setting; it reduces the long-term conversion rate of α-TCP to CDHA in gelatin-α-TCP bone cement and prevents the release of gelatin from gelatin-α-TCP bone cement during immersion in physiological solution[2].
DCPD dissolves rapidly in gelatin-α-TCP bone cements immersed in physiological solutions, and the dissolution rate decreases with the increase of initial DCPD content[2].
DCPD improves the mechanical properties of gelatin-α-TCP bone cement; it alters the morphological development during the curing process of gelatin-α-TCP bone cement, forming a denser surface and smaller crystals at DCPD concentrations of 2.5 wt.% and 5 wt.%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:White Leghorn (3-day/72-76 h embryos)[1]
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Dosage:0.36 μmol per egg; 0.73 μmol per egg; 1.5 μmol per egg; 2.9 μmol per egg
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Administration:local injection onto inner shell membrane over embryo; single dose
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Result:Triggered 3% early deaths, 3% late malformed deaths, 23% malformed survivors and 30% affected embryos at 0.36 μmol per egg.
Triggered 3% early deaths, 57% malformed survivors and 60% affected embryos at 0.73 μmol per egg.
Triggered 83% malformed survivors and 83% affected embryos at 1.5 μmol per egg.
Triggered 10% early deaths, 3% late malformed deaths, 43% malformed survivors and 57% affected embryos at 2.9 μmol per egg.
Exhibited an overall ED50 (deaths plus malformations) of 0.6 μmol per egg.
Induced prevalent small head malformations (96%) plus minor ocular, body wall, skeletal, wing and oedema lesions among 51 malformed embryos with 70 recorded defects.
Chemical Information
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CAS No. 4175-38-6
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Appearance Solid
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분자량 272.43
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화학식 C18H28N2
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Color Brown to reddish brown
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SMILES
C1(NC2CCCCC2)=CC=C(NC3CCCCC3)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 20 mg/mL (73.41 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Korhonen A, et al. Embryotoxicity of sixteen industrial amines to the chicken embryo. Journal of Applied Toxicology. 1983;3(2):112-117. [Content Brief]
[2]. Panzavolta S, et al. Optimization of a biomimetic bone cement: Role of DCPD. Journal of Inorganic Biochemistry. 2011;105(8):1060-1065. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6707 mL | 18.3533 mL | 36.7067 mL | 91.7667 mL |
| 5 mM | 0.7341 mL | 3.6707 mL | 7.3413 mL | 18.3533 mL | |
| 10 mM | 0.3671 mL | 1.8353 mL | 3.6707 mL | 9.1767 mL | |
| 15 mM | 0.2447 mL | 1.2236 mL | 2.4471 mL | 6.1178 mL | |
| 20 mM | 0.1835 mL | 0.9177 mL | 1.8353 mL | 4.5883 mL | |
| 25 mM | 0.1468 mL | 0.7341 mL | 1.4683 mL | 3.6707 mL | |
| 30 mM | 0.1224 mL | 0.6118 mL | 1.2236 mL | 3.0589 mL | |
| 40 mM | 0.0918 mL | 0.4588 mL | 0.9177 mL | 2.2942 mL | |
| 50 mM | 0.0734 mL | 0.3671 mL | 0.7341 mL | 1.8353 mL | |
| 60 mM | 0.0612 mL | 0.3059 mL | 0.6118 mL | 1.5294 mL |
DCPD Related Classifications
HY-171985 Related Classifications
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