Dihydromaniwamycin E
Dihydromaniwamycin E is a heat-shock metabolite with antiviral activity against influenza and SARS-CoV-2 viruses.
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- CAS No.: 3033567-35-7
- 화학식: C10H22N2O2
- 분자량:202.29
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
Influenza, SARS-CoV-2[1]
In Vitro
Dihydromaniwamycin E shows an inhibitory effect against influenza (H1N1) virus infection in MDCK cells by a plaque assay, exhibiting an IC50 of 25.7 μM[1].
Dihydromaniwamycin E displays antiviral activity against SARS-CoV-2, the causative agent of COVID-19 infection, in 293TA cells, exhibiting an IC50 of 19.7 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3033567-35-7
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분자량 202.29
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화학식 C10H22N2O2
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SMILES
CCCCCC/[N+]([O-])=N/[C@@H]([C@@H](O)C)C
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Structure Classification
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Initial Source
Streptomyces sp.
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dihydromaniwamycin E Related Classifications
HY-N10604 Related Classifications
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