DMP 904
DMP 904 is a noncompetitive full corticotropin-releasing factor receptor (CRFR) antagonist. DMP 904 can inhibit CRF-stimulated adenylate cyclase activity and ACTH release. DMP 904 exhibits anti-depressant and anti-anxiety activity.
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- CAS No.: 202579-74-6
- 화학식: C21H28N4O
- 분자량:352.47
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | IC50 |
10 nM
Compound: 2a
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Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP production after 15 mins by enzyme immunoassay
Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP production after 15 mins by enzyme immunoassay
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[PMID: 21865047] |
| HEK293 | IC50 |
10 μM
Compound: 33 DMP-904
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Inhibition of h- CRF mediated increase in adenylate cyclase activity was evaluated in HEK293 cells
Inhibition of h- CRF mediated increase in adenylate cyclase activity was evaluated in HEK293 cells
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[PMID: 10794681] |
Chemical Information
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CAS No. 202579-74-6
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분자량 352.47
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화학식 C21H28N4O
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SMILES
CC1=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN2C(NC(CC)CC)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Li YW, et al. The pharmacology of DMP696 and DMP904, non-peptidergic CRF1 receptor antagonists. CNS Drug Rev. 2005 Spring;11(1):21-52. [Content Brief]
[2]. Nielsen DM, et al. Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice. Eur J Pharmacol. 2004 Sep 19;499(1-2):135-46. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DMP 904 Related Classifications
HY-12132 Related Classifications
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