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Cat. No.: HY-P10224

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G7-18NATE

G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (K_D = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines.

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CAS No.: 936728-13-1
화학식: C₆₇H₈₀N₁₄O₁₉S
분자량:1417.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

G7-18NATE Chemical Structure

CAS No.: 936728-13-1

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
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Bioz

Biological Activity

제품 설명

All EGFR Isoforms :

In Vitro

G7-18NATE (10 μM, 24 h) inhibits cell migration in MDA-MB-468 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 936728-13-1
분자량 1417.50
화학식 C₆₇H₈₀N₁₄O₁₉S
Sequence

cyclo(CH2CO-Trp-Phe-Glu-Gly-Tyr-Asp-Asn-Thr-Phe-Pro-Cys(NH2)-S-)
Sequence Shortening

cyclo(CH2CO-WFEGYDNTFP-Cys(NH2)-S-)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sang J, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019 Oct 17;24(20):3739. [Content Brief]

[2]. Giricz O, et al. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012 Jun;133(2):607-15. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
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수량:
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G7-18NATE

All EGFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

G7-18NATE Related Classifications

HY-P10224 Related Classifications