CHRM5 - cholinergic receptor muscarinic 5 Gene

Also Known as HM5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1133

About CHRM5

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:33,968,497-34,067,458 (from NCBI)

This gene has 3 transcripts (splice variants), 264 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as Adenylate Cyclase inhibition, phosphoinositide degeneration, and Potassium Channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

CHRM5 Products (2)

mRNA Protein Name
NM_001320917.2 NP_001307846.1 muscarinic acetylcholine receptor M5
NM_012125.4 NP_036257.1 muscarinic acetylcholine receptor M5

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20398705 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHRM5 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (47 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 532 a.a.
Protein Preferred Names Protein Names

muscarinic acetylcholine receptor M5

  • acetylcholine receptor, muscarinic 5

CHRM5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHRM5 P08912 CHRM3 Homo sapiens P20309
Confocal
20398705
Intra
CHRM5 P08912 CHRM3 Homo sapiens P20309
Anti Bait CoIP
20398705
Intra
CHRM5 P08912 CHRM3 Homo sapiens P20309
Anti Tag CoIP
20398705
Intra
CHRM5 P08912 CHRM3 Homo sapiens P20309
BRET
20398705
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS02664 CHRM5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21527 Chrm5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28045 Chrm5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CHRM5 VGNC VGNC:39235
Bos taurus CHRM5 VGNC VGNC:27321
Felis catus CHRM5 VGNC VGNC:60877
Rattus norvegicus CHRM5 RGD RGD:620027
Macaca mulatta CHRM5 VGNC VGNC:71044
Mus musculus CHRM5 MGD MGI:109248
Others CHRM5 NCBI