Traf3 - TNF receptor-associated factor 3 Gene

Also Known as amn; LAP1; CAP-1; CRAF1; T-BAM; CD40bp; TRAFAMN

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22031

Summary

Enables protein kinase binding activity. Involved in several processes, including regulation of defense response to virus; regulation of gene expression; and tumor necrosis factor-mediated signaling pathway. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; lower jaw epithelium; lung; and mandibular process. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TRAF3 (TNF Receptor associated factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Traf3 Products (3)

mRNA Protein Name
NM_001286122.1 NP_001273051.1 TNF receptor-associated factor 3 isoform b
NM_001364364.1 NP_001351293.1 TNF receptor-associated factor 3 isoform b
NM_011632.3 NP_035762.2 TNF receptor-associated factor 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17158868 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
17015635 MGI
involved in regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
16306937 MGI
involved in regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
16306937 MGI
involved in regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
16306937 MGI
involved in regulation of proteolysis IDA
IDA: Inferred from direct assay
17158868 MGI
involved in regulation of proteolysis IMP
IMP: Inferred from mutant phenotype
17015635 MGI
involved in toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16306937 MGI
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17015635 MGI
Cellular Component GO Annotation Evidence References Source
part of CD40 receptor complex IDA
IDA: Inferred from direct assay
20614026 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
20614026 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TNF receptor-associated factor 3

  • CD40 receptor-associated factor 1

  • CD40-binding protein

  • RING-type E3 ubiquitin transferase TRAF3

Traf3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Traf3 Q60803 TBK1 Homo sapiens Q9UHD2
Anti Bait CoIP
16306936
Cross
Traf3 Q60803 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
27094905
Intra
Traf3 Q60803 Ticam1 Mus musculus Q80UF7
Anti Bait CoIP
16306937
Intra
Traf3 Q60803 Ticam1 Mus musculus Q80UF7
Anti Bait CoIP
16306936
Intra
Traf3 Q60803 Mavs Mus musculus Q8VCF0
Pull Down
16858409
Intra
Traf3 Q60803 Rps27a Mus musculus P62991
Anti Bait CoIP
23334419
Intra
Traf3 Q60803 Rps27a Mus musculus P62991
Anti Bait CoIP
18083102
Intra
Traf3 Q60803 Traf2 Mus musculus P39429
Anti Bait CoIP
20818435
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-185123 Pig TRIM56 mRNA / Unkown
HY-RS14969 TRAF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14970 TRAF3IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14971 TRAF3IP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14972 TRAF3IP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17996 Traf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22078 Traf3ip2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24468 Traf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28597 Traf3ip2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Traf3 NCBI NCBI:7187