Mavs - mitochondrial antiviral signaling protein Gene

Also Known as Visa; IPS-1; cardif; D430028G21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 228607

Summary

Enables signaling adaptor activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of myeloid dendritic cell cytokine production; and regulation of peroxisome organization. Acts upstream of or within RIG-I signaling pathway; positive regulation of defense response to virus by host; and positive regulation of type I interferon production. Located in mitochondrion and peroxisome. Orthologous to human MAVS (mitochondrial Antiviral signaling protein). [provided by Alliance of Genome Resources, Apr 2022]

Mavs Products (4)

mRNA	Protein	Name
NM_001206382.1	NP_001193311.1	mitochondrial antiviral-signaling protein isoform 2
NM_001206383.1	NP_001193312.1	mitochondrial antiviral-signaling protein isoform 2
NM_001206385.1	NP_001193314.1	mitochondrial antiviral-signaling protein isoform 1
NM_144888.2	NP_659137.1	mitochondrial antiviral-signaling protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16858409	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	23582325	MGI
enables signaling adaptor activity	IMP IMP: Inferred from mutant phenotype	20451243	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within RIG-I signaling pathway	IGI IGI: Inferred from genetic interaction	22745163	MGI
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	20451243	MGI
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	23582325	MGI
acts upstream of or within positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	18780793	MGI
acts upstream of or within positive regulation of interferon-alpha production	IMP IMP: Inferred from mutant phenotype	31390091	MGI
acts upstream of or within positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	31390091	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	31390091	MGI
involved in positive regulation of myeloid dendritic cell cytokine production	IMP IMP: Inferred from mutant phenotype	21703541	MGI
acts upstream of or within positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	18780793	MGI
involved in protein localization to mitochondrion	IDA IDA: Inferred from direct assay	23582325	MGI
involved in regulation of peroxisome organization	IMP IMP: Inferred from mutant phenotype	20451243	MGI
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	20451243	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	20451243	MGI
located in peroxisome	IDA IDA: Inferred from direct assay	20451243	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mitochondrial antiviral-signaling protein	CARD adapter inducing interferon beta IFN-beta promoter stimulator-1 interferon beta promoter stimulator protein 1 mitochondrial anti-viral signaling protein virus-induced signaling adapter

Mavs Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Mavs	Q8VCF0	Traf3	Mus musculus	Q60803	Anti Bait CoIP	16858409
Intra	Mavs	Q8VCF0	Traf3	Mus musculus	Q60803	Pull Down	16858409

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y0136	3-Indoleacetonitrile		99.92%	Unkown
HY-123805	KIN1400		98.1%	Unkown
HY-RS08176	MAVS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181526	Sim-9	Inhibitor	/	Unkown
HY-Y0136S1	3-Indoleacetonitrile-d4		/	Unkown
HY-181440	TDG-IN-1	Inhibitor	/	Unkown
HY-113687	T145	Inhibitor	/	Unkown
HY-173128	TZOA	Inhibitor	/	Unkown
HY-RS17037	Mavs Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23481	Mavs Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mavs	NCBI	NCBI:57506