Ticam1 - toll-like receptor adaptor molecule 1 Gene

Also Known as TRIF; TICAM-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 106759

Summary

Predicted to enable protein kinase binding activity. Involved in several processes, including TRIF-dependent Toll-like Receptor signaling pathway; cellular response to oxidised low-density lipoprotein particle stimulus; and positive regulation of cytokine production. Acts upstream of or within several processes, including positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of nitrogen compound metabolic process. Located in cytosol and mitochondrion. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (toll like receptor adaptor molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Ticam1 Products (1)

mRNA Protein Name
NM_174989.5 NP_778154.1 TIR domain-containing adapter molecule 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14517278 MGI
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
21441935 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of B cell activation IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of B cell proliferation IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within MyD88-independent toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12855817 MGI
involved in TRIF-dependent toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17658277 MGI
acts upstream of or within apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
12872135 MGI
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
17658277 MGI
involved in cellular response to oxidised low-density lipoprotein particle stimulus IMP
IMP: Inferred from mutant phenotype
20037584 MGI
acts upstream of chemokine production IGI
IGI: Inferred from genetic interaction
12855817 MGI
acts upstream of chemokine production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within defense response to virus IMP
IMP: Inferred from mutant phenotype
12872135 MGI
acts upstream of interferon-beta production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within macrophage activation involved in immune response IMP
IMP: Inferred from mutant phenotype
12872135 MGI
acts upstream of macrophage cytokine production IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
12872135 MGI
acts upstream of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
12872135 MGI
acts upstream of or within positive regulation of B cell activation IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within positive regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IGI
IGI: Inferred from genetic interaction
12855817 MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
12855817 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
17658277 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
12855817 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within positive regulation of chemokine production IGI
IGI: Inferred from genetic interaction
12855817 MGI
acts upstream of or within positive regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
involved in positive regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
20037584 MGI
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
20037584 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20037584 MGI
acts upstream of or within positive regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within positive regulation of macrophage cytokine production IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of or within positive regulation of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
12872135 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
involved in positive regulation of myeloid dendritic cell cytokine production IMP
IMP: Inferred from mutant phenotype
21703541 MGI
acts upstream of or within positive regulation of natural killer cell activation IMP
IMP: Inferred from mutant phenotype
21059856 MGI
acts upstream of or within positive regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
12872135 MGI
acts upstream of or within positive regulation of protein binding IDA
IDA: Inferred from direct assay
19734906 MGI
acts upstream of or within positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
19734906 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
12872135 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of or within positive regulation of type I interferon production IMP
IMP: Inferred from mutant phenotype
12872135 MGI
acts upstream of or within regulation of protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
12872135 MGI
acts upstream of or within response to exogenous dsRNA IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of or within response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
12855817 MGI
involved in response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
21703541 MGI
acts upstream of or within response to lipopolysaccharide IGI
IGI: Inferred from genetic interaction
12872135 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of tumor necrosis factor production IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
12872135 MGI
acts upstream of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
12855817 MGI
acts upstream of type I interferon production IMP
IMP: Inferred from mutant phenotype
12872135 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
21703541 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
21703541 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TIR domain-containing adapter molecule 1

  • TIR domain-containing adapter protein inducing IFN-beta

  • TIR domain-containing adaptor inducing interferon-beta

  • toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

Ticam1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ticam1 Q80UF7 Btk Mus musculus P35991
Anti Tag CoIP
21441935
Intra
Ticam1 Q80UF7 Tbk1 Mus musculus Q9WUN2
Anti Bait CoIP
22454496
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14517 TICAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ticam1 NCBI NCBI:148022