IFNL3 - interferon lambda 3 Gene

Also Known as IL28B; IL28C; IL-28B; IL-28C; IFN-lambda-3; IFN-lambda-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 282617

About IFNL3

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,243,455-39,245,250 (from NCBI)

This gene has 2 transcripts (splice variants), 136 orthologues, 2 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral Infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

IFNL3 Products (2)

mRNA Protein Name
NM_001346937.2 NP_001333866.1 interferon lambda-3 isoform 1
NM_172139.4 NP_742151.2 interferon lambda-3 isoform 2 precursor

IFNL3 Protein Structure

IL28A

IL28A: Interleukin-28A (33 - 193)

  • 0
  • 100
  • 196 a.a.
Protein Preferred Names Protein Names

interferon lambda-3

  • cytokine Zcyto22

Recombinant IFNL3 Proteins

Cat. No. 상품명 Accession Purity
HY-P72552 IFN-lambda 3/IL-28B Protein, Human (HEK293, His) Q8IZI9 (V22-V196) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700120AF Animal-Free IFN-lambda 3/IL-28B Protein, Human (His) Q8IZI9 (V22-V196) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hepatitis C Virus

  • Hepatitis C Virus, Susceptibility To

  • Hepatitis C Virus Infection, Response To Therapy Of

  • Hcv

  • Hcv, Susceptibility To

  • Hepatitis C Virus, Resistance To

  • Hepatitis C Virus, Response To Therapy Of

  • Resistance To Hepatitis C Virus
Cryoglobulinemia

  • Cryoimmunoglobulinaemia
Hepatitis D

  • Delta Hepatitis

  • Hepatitis Delta

  • Hdv

  • Hepatitis D Virus

  • Hepatitis D Infection
Viral Hepatitis

  • Animal Viral Hepatitis

  • Hepatitis, Viral, Animal

  • Human Viral Hepatitis

  • Viral Hepatitis With Hepatic Coma
Hepatitis E
Liver Cirrhosis

  • Cirrhosis

  • Cirrhosis Of Liver

  • CIRRH

  • Cryptogenic Cirrhosis

  • Cirrhosis, Cryptogenic

  • Cirrhosis Nos
Abacavir Allergy

  • Abc Allergy
Esophageal Varix

  • Esophageal Varices

  • Bleeding Esophageal Varices

  • Bleeding Oesophageal Varices

  • Esophageal Varices In Disease Classified Elsewhere, With Bleeding

  • Esophageal Varices With Bleeding

  • Esophageal Varices With Bleeding In Disease Ec

  • Esophageal Varices Without Bleeding

  • Esophageal Varices Without Mention Of Bleeding
Bilirubin Metabolic Disorder

  • Hyperbilirubinemia

  • Hereditary Hyperbilirubinemia

  • Hyperbilirubinemia, Hereditary

  • Hyperbilirubinaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS06593 IFNL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174658 Human IFNL3 mRNA / Unkown
HY-RS19446 Ifnl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25938 Ifnl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IFNL3 RGD RGD:1589046