E2f7 - E2F transcription factor 7 Gene

Also Known as E2F-7; D10Ertd739e; A630014C11Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 52679

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including hepatocyte differentiation; regulation of cell cycle process; and trophoblast giant cell differentiation. Acts upstream of or within negative regulation of cell population proliferation and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in brain; embryo mesenchyme; and genitourinary system. Orthologous to human E2F7 (E2F transcription factor 7). [provided by Alliance of Genome Resources, Apr 2022]

E2f7 Products (2)

mRNA	Protein	Name
NM_001358560.2	NP_001345489.1	transcription factor E2F7
NM_178609.6	NP_848724.2	transcription factor E2F7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12893818	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	22516201	MGI
enables DNA-binding transcription repressor activity	IDA IDA: Inferred from direct assay	22180533	MGI
enables DNA-binding transcription repressor activity	IMP IMP: Inferred from mutant phenotype	22516201	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12893818	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22180533	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12893818	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22903062	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in chorionic trophoblast cell differentiation	IMP IMP: Inferred from mutant phenotype	22516201	MGI
involved in hepatocyte differentiation	IMP IMP: Inferred from mutant phenotype	23064266	MGI
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	22180533	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12893818	MGI
involved in negative regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	23064266	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12893818	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22516201	MGI
involved in placenta development	IMP IMP: Inferred from mutant phenotype	22516201	MGI
involved in positive regulation of DNA endoreduplication	IMP IMP: Inferred from mutant phenotype	23064266	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12893818	MGI
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	22903062	MGI
involved in trophoblast giant cell differentiation	IMP IMP: Inferred from mutant phenotype	23064266	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	12893818	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor E2F7

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS04116	E2F7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18926	E2f7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25416	E2f7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	E2f7	NCBI	NCBI:144455