RPS6 - ribosomal protein S6 Gene

Also Known as S6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6194

About RPS6

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:19,375,715-19,380,236 (from NCBI)

This gene has 5 transcripts (splice variants) and 184 orthologues. Ubiquitous expression in ovary (RPKM 2180.7), bone marrow (RPKM 1555.2) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS6 Products (1)

mRNA Protein Name
NM_001010.3 NP_001001.2 40S ribosomal protein S6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16314389 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21418524 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
8706699 GOA
enables structural constituent of ribosome IMP
IMP: Inferred from mutant phenotype
18697920 GOA
Biological Process GO Annotation Evidence References Source
involved in TOR signaling IDA
IDA: Inferred from direct assay
16428328 GOA
involved in cytoplasmic translation IDA
IDA: Inferred from direct assay
8706699 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
18362888 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17220279 GOA
involved in rRNA processing IMP
IMP: Inferred from mutant phenotype
18697920 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
involved in ribosomal small subunit biogenesis IMP
IMP: Inferred from mutant phenotype
18697920 GOA
Cellular Component GO Annotation Evidence References Source
located in cell body IDA
IDA: Inferred from direct assay
15121898 GOA
located in cytoplasmic ribonucleoprotein granule IDA
IDA: Inferred from direct assay
15121898 GOA
is active in cytosolic ribosome IDA
IDA: Inferred from direct assay
8706699 GOA
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: Inferred from direct assay
8706699 GOA
located in dendrite IDA
IDA: Inferred from direct assay
15121898 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
8590812 GOA
located in nucleus IDA
IDA: Inferred from direct assay
2334893 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
18809582 GOA
part of small ribosomal subunit IDA
IDA: Inferred from direct assay
15590835 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6 Protein Structure

Ribosomal_S6e

Ribosomal_S6e: Ribosomal protein S6e (1 - 127)

  • 0
  • 100
  • 200
  • 249 a.a.
Protein Preferred Names Protein Names

40S ribosomal protein S6

  • phosphoprotein NP33

RPS6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPS6 P62753 PASK Homo sapiens Q96RG2
Peptide Array
21418524
Intra
RPS6 P62753 PASK Homo sapiens Q96RG2
Protein Kinase Assay
21418524
Cross
RPS6 P62753 N SARS-CoV-2 P0DTC9
Y2H Array
36217030
Intra
RPS6 P62753 NCBP1 Homo sapiens Q09161
Anti Tag CoIP
18423201
Intra
RPS6 P62753 NCBP1 Homo sapiens Q09161
Anti Bait CoIP
18423201
Intra
RPS6 P62753 NPM1 Homo sapiens P06748
Crosslink
30021884
Intra
RPS6 P62753 NPM1 Homo sapiens P06748
BioID
29568061
Cross: Cross-species interaction Intra: Intraspecies interaction

RPS6 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P80885 RPS6 Antibody (YA677) WB, ICC/IF, IP Human, Mouse, Rat, Monkey
HY-P80885A RPS6 Antibody (YA677)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat, Monkey
HY-P83767 Phospho-RPS6 (Ser235/Ser236) Antibody (YA3570) WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P83767A Phospho-RPS6 (Ser235/Ser236) Antibody (YA3570) (PBS only) WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P86147 Phospho-RPS6(Ser240/Ser244) Antibody (YA5839) WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P86147A Phospho-RPS6(Ser240/Ser244) Antibody (YA5839)(PBS only) WB, IHC-P, ICC/IF Human, Mouse
HY-P86216 RPS6 Antibody (YA5908) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P86216A RPS6 Antibody (YA5908)(PBS only) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Tuberous Sclerosis

  • Tuberous Sclerosis Syndrome

  • Bourneville'S Disease

  • Epiloia

  • Cerebral Sclerosis

  • Tuberose Sclerosis

  • Tuberous Sclerosis 1

  • Bourneville Disease

  • Bourneville Phakomatosis

  • Pringle'S Disease
Lymphangioleiomyomatosis

  • Lymphangiomyomatosis

  • LAM

  • Lung Lymphangioleiomyomatosis

  • Pulmonary Lymphangioleiomyomatosis

  • Lymphangioleiomyomatosis, Somatic

  • Lymphangio-Myomatosis
Squamous Cell Carcinoma

  • Epidermoid Carcinoma

  • Squamous Cell Cancer

  • Carcinoma, Squamous Cell

  • Squamous Cell Skin Cancer

  • Malignant Squamous Cell Tumor

  • Squamous Carcinoma

  • Squamous Cell Epithelioma

  • Carcinoma Squamous Cell

  • Neoplasms, Squamous Cell

  • Squamous Cell Carcinoma - Category

  • Malignant Squamous Cell Neoplasm

  • Squamous Cell Carcinoma Of Skin
Muscle Hypertrophy

  • MSLHP

  • Hypertrophy

  • Hypertrophy, Muscle
Motor Neuron Disease

  • Anterior Horn Cell Disease

  • Motor Neuron Diseases

  • Mnd - [Motor Neurone Disease]

  • Lou Gehrig Disease

  • Creeping Palsy

  • Creeping Paralysis

  • Bulbar Motor Neuron Disease

  • Bulbar Syndrome

  • Anterior Horn Cell Disorder

  • Hereditary Motor Neuron Disease
Subependymal Glioma

  • Mixed Subependymoma-Ependymoma

  • Subependymal Astrocytoma

  • Who Grade I Ependymal Tumor

  • Glioma, Subependymal
Kidney Angiomyolipoma

  • Angiomyolipoma Of Kidney

  • Renal Angiomyolipoma
Diamond-Blackfan Anemia 6

  • DBA6

  • Aase-Smith Syndrome Ii

  • Aase Syndrome

  • Aase Smith Syndrome 2

  • Rpl5-Related Diamond-Blackfan Anemia

  • Anemia, Diamond-Blackfan, Type 6

  • Diamond-Blackfan Anemia 1
Rett Syndrome

  • Atypical Rett Syndrome

  • RTT

  • Rett Disorder

  • Rts

  • Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

  • Rett Syndrome, Preserved Speech Variant

  • Rett Syndrome, Atypical

  • Rett'S Disorder

  • Rett Syndrome Variant

  • Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

  • Cerebroatrophic Hyperammonemia

  • Rett Like Syndrome

  • Rett'S Syndrome

  • Atypical Rtt

  • Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

  • Rett Syndrome Preserved Speech Variant

  • Rett Syndrome Zappella Variant

  • Rett Syndrome, Zappella Variant
Pyriform Sinus Cancer

  • Malignant Neoplasm Of Pyriform Fossa

  • Malignant Neoplasm Of The Pyriform Fossa

  • Malignant Tumor Of Pyriform Fossa
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Cowden Syndrome

  • Cowden Disease

  • Multiple Hamartoma Syndrome

  • Cowden'S Disease

  • Lhermitte-Duclos Disease

  • Cd

  • Cs

  • Mham

  • Dysplastic Gangliocytoma Of Cerebellum

  • Cowden'S Syndrome

  • Hamartoma Syndrome, Multiple
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (41)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-123919 TL13-112 Inhibitor 98.01% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-13495 ML281 98.04% Unkown
HY-122582 TL13-12 Degrader 98.16% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148062 RSS0680 Degrader 99.85% Unkown
HY-148063 DB0614 99.92% Unkown
HY-W070306 PDK1-IN-1 Inhibitor 99.95% Unkown
HY-RS12247 RPS6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-50733 CX-5011 free base / Unkown
HY-150643 RSK2-IN-2 Inhibitor / Unkown
HY-150717 RSK2-IN-3 Inhibitor / Unkown
HY-161874 RPS6-IN-1 / Unkown
HY-RS12248 RPS6KA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12249 Rps6ka1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12250 Rps6ka1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12251 RPS6KA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12252 Rps6ka2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12253 Rps6ka2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12254 RPS6KA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12255 Rps6ka3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12256 Rps6ka3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12257 RPS6KA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12258 RPS6KA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12259 RPS6KA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12260 Rps6ka6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12261 Rps6ka6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12262 RPS6KB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12263 Rps6kb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12264 Rps6kb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12265 RPS6KB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12266 Rps6kb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12267 Rps6kb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12268 RPS6KC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183393 NVP-BHS345 Inhibitor / Unkown
HY-RS17694 Rps6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22025 Rps6ka4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22026 Rps6ka5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24156 Rps6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28543 Rps6ka4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28544 Rps6ka5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RPS6 MGD MGI:98159
Felis catus RPS6 VGNC VGNC:97612
Rattus norvegicus RPS6 RGD RGD:3602
Others RPS6 NCBI