Griselimycin
Based on 1 Customer Validation
Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.2%
- CAS No.: 26034-16-2
- 화학식: C57H96N10O12
- 분자량:1113.43
-
보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
Griselimycin (0-200 μM) binds to β-clamp homologs from various Gram-negative and Gram-positive bacteria with high selectivity and variable affinities ranging from submicromolar to nanomolar, among which the interaction with Bartonella birtlesii β-clamp is the strongest (Kd = 6.9 nM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 26034-16-2
-
Appearance Solid
-
분자량 1113.43
-
화학식 C57H96N10O12
-
Color White to off-white
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
순도&문서
-
Data Sheet (258 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Holzgrabe U, et al. New Griselimycins for Treatment of Tuberculosis. Chem Biol. 2015;22(8):981-982. [Content Brief]
[2]. Fenwick MK, et al. Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens. Commun Biol. 2024;7(1):1622. Published 2024 Dec 5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Griselimycin Related Classifications
HY-125576 Related Classifications
Powered by Bioz