hCA-IN-1
hCA-IN-1 (Compound 5u) is an hCA inhibitor with Ki values of 159.2, 4.8, 15.5, and 2 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. hCA-IN-1 exhibits broad-spectrum anticancer activity against melanoma, breast, and colon cancer cells. ADME predictions indicate that hCA-IN-1 has good solubility and oral bioavailability. hCA-IN-1 can be used in tumor research.
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- 화학식: C20H18N4O4S3
- 분자량:474.58
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
hCA I 159.2 nM (Ki) |
hCA II 4.8 nM (Ki) |
hCA IX 15.5 nM (Ki) |
hCA XII 2 nM (Ki) |
Chemical Information
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분자량 474.58
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화학식 C20H18N4O4S3
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SMILES
O=C(C(SC(SCC(NC1=CC=C(S(=O)(N)=O)C=C1)=O)=N2)=C2C)/C=C/C3=NC=CC=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)