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Cat. No.: HY-N19860

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L-Balenine

L-Balenine is an orally active Pin1 inhibitor and intracellular pH buffer. L-Balenine enhances the phagocytic activity of macrophages, and promotes the expression of pro-inflammatory and anti-inflammatory cytokines during muscle degeneration. L-Balenine also upregulates the expression of myogenic marker genes associated with regeneration, thereby effectively driving skeletal muscle regeneration. L-Balenine can be widely used in studies related to skeletal muscle injury and its repair mechanisms.

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CAS No.: 331-38-4
화학식: C₁₀H₁₆N₄O₃
분자량:240.26

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

L-Balenine Chemical Structure

CAS No.: 331-38-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

L-Balenine (10 mM; 24 h) dose-dependently enhances the phagocytic activity of RAW264.7 macrophage cells^[1].
L-Balenine (10 mM; 24 h) significantly enhances the phagocytic uptake of opsonized E. coli BioParticles by RAW264.7 macrophage cells, increasing bead uptake per cell to 2.38 times the control level^[1].
L-balenine (2-4 mM; 60 seconds) potently and specifically inhibits the PPIase catalytic activity of purified recombinant Pin1 in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dietary balenine-enriched extract (1% w/w balenine-enriched extract (containing 27.3% balenine); p.o.; ad libitum; 2 weeks prior to CTX injection and up to 14 days post-injection) promotes skeletal muscle regeneration in a Cardiotoxin (CTX)-induced injury model by increasing muscle wet weight retention, reducing inter-membrane space during regeneration, and upregulating expression of myogenic and inflammatory cytokine genes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 6 weeks old at study start, CTX-induced skeletal muscle injury)^[1]
Dosage:

1% w/w balenine-enriched extract (containing 27.3% balenine)
Administration:

p.o.; ad libitum; 2 weeks prior to Cardiotoxin (CTX) injection and up to 14 days post-injection
Result:

Increased wet weight of CTX-injected TA muscle significantly compared to normal diet group at day 3 post-CTX injection.
Increased wet weight of CTX-injected TA muscle significantly at day 14 post-CTX injection compared to day 0, with no significant differences between days 0, 3, and 7.
Reduced average cell-to-cell membrane space in TA muscle to approximately 40% of that in normal diet group at day 7 post-CTX injection.
Upregulated relative mRNA expression of Pax7, MyoD1, myogenin, TNF-α, MCP-1, TGF-β1, and IL-10 significantly compared to normal diet group at day 3 post-CTX injection.
Upregulated relative mRNA expression of Myh3 significantly compared to normal diet group at day 7 post-CTX injection.

Chemical Information

CAS No. 331-38-4
분자량 240.26
화학식 C₁₀H₁₆N₄O₃
SMILES

NCCC(N[C@H](C(O)=O)CC1=CN(C)C=N1)=O
Structure Classification
- Others
Initial Source
- Animals
Freshwater turtles
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yang M, et al. Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells. Mar Drugs. 2022;20(5):313. Published 2022 May 5. [Content Brief]

[2]. Takahashi K, et al. L-balenine inhibits the catalytic activity of Pin1, a peptidyl prolyl cis/trans-isomerase[J]. Personalized Medicine Universe, 2020, 9: 51-58.

[3]. Dolan E, et al. Skeletal muscle histidine-containing dipeptide contents are increased in freshwater turtles (C. picta bellii) with cold-acclimation[J]. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2021, 262: 111071.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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