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Cat. No.: HY-P11904

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LADW

LADW is a tetrapeptide derived from the hydrolysate of tuna skeletal muscle myosin, with dual inhibitory activities against angiotensin-converting enzyme 1 (ACE1) and α-glucosidase. The IC₅₀ value of LADW against ACE1 is 28.02 μM, while its IC₅₀ value against Saccharomyces cerevisiae α-glucosidase is 4.40 mM. LADW binds competitively to the active site of ACE1, stabilizes the enzyme conformation, and blocks substrate binding. LADW binds to α-glucosidase to inhibit carbohydrate hydrolysis and can also alter starch structure. LADW can be used in studies related to hypertension and diabetes.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₄H₃₃N₅O₇
분자량:503.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

맞춤형 펩타이드 합성

LADW Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

OthersCardiovascular RegulationLocal Vascular RegulationCarbohydrate Metabolism

Others

LADW is a competitive inhibitor of purified ACE1, which binds to the active site of the enzyme or its adjacent region to block substrate binding. It potently inhibits purified ACE1 with an IC₅₀ of 28 μM, exhibiting a concentration-dependent inhibitory effect^[1].

Cardiovascular Regulation

Local Vascular Regulation

LADW (150-300 μM; 24 h) promotes NO release and inhibits ET-1 secretion in EA.hy926 vascular endothelial cells in a concentration-dependent manner^[1].
LADW forms strong interactions with eNOS, ECE-1 and Furin via hydrogen bonds and van der Waals forces and binds to the key active residues of these proteins according to molecular docking results^[1].

Carbohydrate Metabolism

LADW (15 min pre-incubation followed by 15 min reaction) potently inhibits α-glucosidase derived from Saccharomyces cerevisiae, with an IC₅₀ value of 4.40 mM, and its inhibitory activity is stronger than that of EEAEGT^[2].
LADW inhibits the hydrolysis of soluble starch during simulated gastrointestinal digestion by altering starch structure, reducing the production of reducing sugars by 39.56%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

EA.hy926 vascular endothelial cells
Concentration:

150 μM, 300 μM
Incubation Time:

24 h
Result:

Increased NO release by 45.88% (150 μM) and 78.94% (300 μM) compared to controls.
Reduced ET-1 secretion by 22.34% (150 μM) and 60.79% (300 μM) compared to controls.

Related Protocols :

Chemical Information

분자량 503.55
화학식 C₂₄H₃₃N₅O₇
Sequence

Leu-Ala-Asp-Trp
Sequence Shortening

LADW
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Xiong W Y, et al. Effects and mechanisms of a novel peptide LADW on angiotensin I‑converting enzyme and vascular function and its gastrointestinal stability: an in vitro and in silico study. Food Bioscience, 2025, 71: 107345.

[2]. Zhao S, et al. Exploring the Blood Glucose-Lowering Potential of the Umami Peptides LADW and EEAEGT Derived from Tuna Skeletal Myosin: Perspectives from α-Glucosidase Inhibition and Starch Interaction. Foods (Basel, Switzerland). 2024 Jan 17;13(2):294.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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