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Cat. No.: HY-118098

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LY3202626

LY3202626 is a CNS penetrant BACE inhibitor with IC₅₀s of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively.

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CAS No.: 1628690-73-2
화학식: C₂₂H₂₀F₂N₈O₂S
분자량:498.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

LY3202626 Chemical Structure

CAS No.: 1628690-73-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

LY3202626 is a CNS penetrant BACE inhibitor with IC₅₀s of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively^[1].

IC₅₀ & Target

IC50: 0.615 nM (BACE1), 0.871 nM (BACE2)^[1]

All Beta-secretase Isoforms :

BACE1
BACE2

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.615 nM Compound: 7; LY-3202626	Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells after 16 to 24 hrs by FRET assay Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells after 16 to 24 hrs by FRET assay	[PMID: 30709653]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1628690-73-2
분자량 498.51
화학식 C₂₂H₂₀F₂N₈O₂S
SMILES

O=C(NC1=CC=C(C([C@@]23N=C(SC[C@@]2(CN(C3)C4=NC=C(C=N4)F)[H])N)=C1)F)C5=NC=C(N=C5)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. McKinzie DL, et al. Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor. J Med Chem. 2021 Jun 24;64(12):8076-8100. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Clinical Trial
Chemical Information
순도&문서
References

상품명:
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수량:
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LY3202626

All Beta-secretase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

LY3202626 Related Classifications

HY-118098 Related Classifications