MK-1832
MK-1832 (Compound 32) is a selective Kv1.5 inhibitor (IC50 = 86 nM). MK-1832 is a P-glycoprotein substrate. MK-1832 can be used in atrial fibrillation research.
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- CAS No.: 935868-50-1
- 화학식: C23H17Cl2N3O
- 분자량:422.31
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>30000 nM
Compound: 2; MK-1832; ent-32
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Displacement of [3H]-MK499 from human ERG IKr channel expressed in HEK293 cell membranes
Displacement of [3H]-MK499 from human ERG IKr channel expressed in HEK293 cell membranes
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[PMID: 28131713] |
Chemical Information
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CAS No. 935868-50-1
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분자량 422.31
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화학식 C23H17Cl2N3O
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SMILES
O[C@@H](C1=CC=CN=C1C2=CC(Cl)=CC(Cl)=C2)C(C3=CC=CN=C3)C4=CC=CN=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MK-1832 Related Classifications
HY-123793 Related Classifications
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