country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-189098

Copy Link Print Information

N-0159

N-0159 is a type II transmembrane serine protease (TTSP) inhibitor with anti-influenza virus activity. N-0159 exhibits a K_i of 0.06 nM against matriptase and acts through competitive and reversible inhibition of matriptase catalytic activity. N-0159 inhibits H1N1 influenza virus replication in human bronchial epithelial cells (IC₅₀ = 292 nM). N-0159 can be used for research related to influenza virus infection.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3068741-64-7
화학식: C₃₄H₄₈N₁₂O₅S
분자량:736.89

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

N-0159 Chemical Structure

CAS No.: 3068741-64-7

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
Calu-3	IC50	292 nM	Inhibition of H1N1 virus replication in human bronchial epithelial Calu-3 cells infected with A/Puerto Rico/8/34 (PR8) at an MOI of 0.003, with viral titers evaluated 48 hrs post-infection. Inhibition of H1N1 virus replication in human bronchial epithelial Calu-3 cells infected with A/Puerto Rico/8/34 (PR8) at an MOI of 0.003, with viral titers evaluated 48 hrs post-infection.	37864572

In Vitro

OthersViral Infection

Others

N-0159 (compound 15d) effectively inhibits recombinant human matriptase with a K_i value of 0.06 nM.
N‑0159 features homophenylalanine at the P2 position, which increases side‑chain flexibility and promotes additional π‑aromatic interactions within the matriptase active site, accounting for its higher affinity relative to IN‑2^[1].

Viral Infection

N-0159 inhibits H1N1 virus replication in Calu-3 cells with an IC₅₀ of 292 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

CAS No. 3068741-64-7
분자량 736.89
화학식 C₃₄H₄₈N₁₂O₅S
SMILES

N=C(N)NCCC[C@H](N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(C2=NC3=CC=CC=C3S2)=O)=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Colombo É, et al. Optimization of Ketobenzothiazole-Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication. ChemMedChem. 2024 Jan 15;19(2):e202300458.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기