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Cat. No.: HY-182510

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NTZ-24

NTZ-24 is a selective STAT3 pathway inhibitor. NTZ-24 suppresses STAT3 phosphorylation at Tyr705, blocks STAT3-DNA interaction, and downregulates the levels of STAT3 downstream target proteins. NTZ-24 induces cell-cycle arrest and promotes apoptosis in cancer cells. NTZ-24 exerts significant antiproliferative activity against HeLa cells (IC₅₀ = 3.3 μM). NTZ-24 can be used for the research of cervical cancer.

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CAS No.: 69819-42-7
화학식: C₁₀H₅Cl₂N₃O₃S
분자량:318.14

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NTZ-24 Chemical Structure

CAS No.: 69819-42-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

STAT3

0.8 μM (IC₅₀)

IL-6

All STAT Isoforms :

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	3.3 μM Compound: 24	Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay	[PMID: 34055214]

In Vitro

NTZ-24 (compound 24) inhibits the IL-6/JAK/STAT3 pathway in HEK-Blue IL-6 cells with an IC₅₀ of 0.8 μM^[1].
NTZ-24 (48 h) inhibits the proliferation of HeLa epithelial carcinoma cells with an IC₅₀ of 3.3 μM^[1].
NTZ-24 (10-50 μM; 48 h) exhibits low cytotoxicity in human normal embryonic kidney HEK 293T cells, with 8.0% and 19.1% cell viability inhibition at 10 μM and 50 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 69819-42-7
분자량 318.14
화학식 C₁₀H₅Cl₂N₃O₃S
SMILES

O=C(C1=CC=C(C(Cl)=C1)Cl)NC2=NC=C([N+]([O-])=O)S2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Lü Z, et al. Structure-Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors. ACS Med Chem Lett. 2021;12(5):696-703. Published 2021 Apr 1. [Content Brief]

Calculators

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Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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NTZ-24

All STAT Isoforms

All Interleukin Related Isoforms