DGKG

DGKγ completes the type I branch of diacylglycerol kinases together with DGKα and DGKβ. Like its relatives, it possesses a recoverin homology domain with EF-hand motifs and two C1 domains, and its activity is regulated by calcium and by membrane recruitment. DGKγ is particularly enriched in the brain, where it modulates DAG pools downstream of receptor-driven phosphoinositide hydrolysis and thereby influences PKC-dependent synaptic signaling and neuronal plasticity. Work in cultured cells also links DGKγ to control of cell-cycle progression, proliferation, and membrane-trafficking events at the Golgi and plasma membrane. Its two C1 domains additionally allow direct binding of DAG, coupling enzyme recruitment to the very signal it consumes.