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Cat. No.: HY-150286A

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(R)-SM875

(R)-SM875 is a degrader targeting the intermediate folding form of prion protein (PrP). (R)-SM875 significantly reduces the PrP level, with an IC₅₀ of 3 μM. (R)-SM875 can be used for the study of prion diseases.

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CAS No.: 2715974-36-8
화학식: C₁₉H₁₆BrN₃O₃
분자량:414.25

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

(R)-SM875 Chemical Structure

CAS No.: 2715974-36-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

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Chemical Information

CAS No. 2715974-36-8
분자량 414.25
화학식 C₁₉H₁₆BrN₃O₃
SMILES

O=C1NC2=C(C=NN2C3=CC=C(C=C3)Br)[C@@H](C4=CC(OC)=C(C=C4)O)C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Innocenti N, et al. Enantiomers of the prion protein degrader SM875: Production and configurational assignment, in silico analysis and in vitro evaluation. Bioorg Chem. 2025 Jul 1;161:108489. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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