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Cat. No.: HY-179606

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RWT9996

RWT9996 is a GPR17 antagonist. RWT9996 inhibits GPR17-mediated signal transduction processes, including G protein activation and β-arrestin-2 recruitment. RWT9996 inhibits MDL-29951 (HY-16312)-mediated phosphorylation of ERK1/2, phosphorylation of CREB, and accumulation of inositol phosphate (IP1) in oligodendrocyte precursor cells in vitro. RWT9996 can be used in studies related to demyelinating diseases.

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CAS No.: 2877694-62-5
화학식: C₁₇H₁₂FN₃O₂S
분자량:341.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

RWT9996 Chemical Structure

CAS No.: 2877694-62-5

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

ERK1

ERK2

Arrestin-3/β-Arrestin 2

All Arrestin Isoforms :

All ERK Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

RWT9996 (12 min) potently inhibits MDL-29951-mediated activation of Gαi2, Gαz and Gα12 in FlpIn-HEK293-hGPR17S cells, with pK_B values ranging from 7.7 to 8.3, but induces non-specific effects^[1].
RWT9996 potently inhibits MDL-29951-mediated recruitment of β-arrestin-2 to GPR17 in HEK293T cells^[1].
RWT9996 (pre-incubated for 10 min, stimulated for 2 min) potently inhibits ERK1/2 phosphorylation in differentiated Oli-neu cells with a pIC₅₀ value of 8.2; it potently inhibits the first phase of CREB phosphorylation induced by MDL-29951 (HY-16312) with a pIC₅₀ of 8.1; and it inhibits IP1 accumulation with a pIC50 of 7.0, where this accumulation is slightly enhanced by Barbadin (HY-119706)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2877694-62-5
분자량 341.36
화학식 C₁₇H₁₂FN₃O₂S
SMILES

FC1=C(NS(C2=CNC(C3=CC=CC=C3)=C2)(=O)=O)C=CC(C#N)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. McDonald JK, et al. G Protein: β-Arrestin Bias Confers Differential Regulation of Gα Signaling by GPR17 Antagonists. ACS chemical neuroscience. 2025 Dec 03;16(23):4479-4491. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

RWT9996

All Arrestin Isoforms

All ERK Isoforms

All Epigenetic Reader Domain Isoforms