country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-124253

Copy Link Print Information

SMDC818909

SMDC818909 is an indole amide-derived uncompetitive inhibitor targeting p97 AAA+ ATPase, with an IC₅₀ of 3.5 μM and a K_a of 9.1 μM. SMDC818909 binds to the D2 ATPase domain of p97, preferentially associates with the ADP-bound conformation of p97, allosterically blocks the ATP hydrolysis cycle of p97, and inhibits its mediated intracellular protein homeostasis regulatory function. SMDC818909 is applied to the research and development of p97-targeted antitumor drugs, as well as studies on cancer-related proteotoxic stress mechanisms.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1147823-21-9
화학식: C₁₄H₁₃N₅O
분자량:267.29

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SMDC818909 Chemical Structure

CAS No.: 1147823-21-9

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

SMDC818909 binds to the D2 domain of full-length p97 with a K_d of 9.1 μM^[1].
SMDC818909 (5-100 μM ATP) acts as a non-competitive inhibitor of p97 ATPase, with IC₅₀ values of 26 μM, 11.5 μM and 4.9 μM under the conditions of 5, 20 and 100 μM ATP, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1147823-21-9
분자량 267.29
화학식 C₁₄H₁₃N₅O
SMILES

O=C(NC1=CC2=C(C=C1)NC(C)=C2)C3=NC=CN=C3N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Alverez C, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. ACS Med Chem Lett. 2015;7(2):182-187. Published 2015 Dec 22. [Content Brief]

[2]. Bulfer S L, Arkin M R. Applying Biophysical and Biochemical Methods to the Discovery of Allosteric Modulators of the AAA ATPase p97[J]. Applied Biophysics for Drug Discovery, 2017: 217-240.

[3]. Carder E J. Synthetic Efforts toward p97 AAA+ ATPaseand p75 Neurotrophin Receptor Inhibitors[D]. University of Pittsburgh, 2019.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기